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Table 4 Results of regression analyses for the primary analysis (with comorbidity score)

From: Quality of life assessment in interstitial lung diseases:a comparison of the disease-specific K-BILD with the generic EQ-5D-5L

  K-BILD
  EQ-5D EBVS VAS Total Breathlessness and activity Chest symptoms Psychological impact
  Parameter Estimate Estimate Estimate Estimate Estimate Estimate
Sex (Ref = Male) Female −0.016 2.63 −0.99 −1.39 − 0.90 − 1.49
Age   0.003** −0.02 0.12 0.06 0.22 0.13
Education Basic −0.05* −5.44 −1.85 −4.47 − 1.66 − 0.84
(Ref = higher) Secondary 0.03 −0.65 0.24 0.16 2.86 0.14
Employment Full-time 0.11** 6.05 3.78 5.85 7.19 2.31
(Ref = retired) Part-time 0.07 7.9 3.39 7.26 2.13 3.27
  Not employed −0.02 −3.38 −0.23 −1.03 −3.49 −0.19
Clinic (Ref = GH) Heidelberg 0.03 1.86 2.28 3.61 4.25 3.05
Smoking status
(Ref = smoker)
Never smoker 0.03 0.75 6.00 3.01 6.45 9.53*
Former Smoker −0.02 0.45 −2.69 −4.52 −4.71 −2.59
FVC % pred   0.002*** 0.19* 0.15** 0.28*** 0.27** 0.16**
DLCO % pred −0.0004 −0.06 0.07 0.20* −0.004 0.06
Disease Subtype
(Ref = other)
IPF 0.07* 8.39* 3.51 7.85* 3.62 2.71
Sarcoidosis −0.001 −0.49 − 0.90 −4.34 − 5.71 0.67
HP 0.02 0.73 3.33 3.29 4.89 4.43
Other IIPs1 0.09* 8.78 4.70 5.48 1.16 7.29*
Comorbidity sum score   −0.03*** −2.72** −1.51** −3.06*** − 2.68** − 1.44*
  1. Values depicted are the beta estimates of regression coefficients. Abbreviations: IPF-idiopathic pulmonary fibrosis, HP-Hypersensitivity pnemonitis, GH-Großhansdorf. 1including: non-specific interstitial pneumonia, desquamative interstitial pneumonia, cryptogenetic organizing pneumonia, lymphocytic interstitial pneumonia,respiratory bronchiolitis-associated interstitial lung disease, pleuropulmonary fibroelastosis, and acute interstitial pneumonia. *p ≤ 0.05, **p ≤ 0.01, ***p ≤ 0.001