Quality of life assessment in interstitial lung diseases:a comparison of the disease-specific K-BILD with the generic EQ-5D-5L

Table 4 Results of regression analyses for the primary analysis (with comorbidity score)

				K-BILD
		EQ-5D EBVS	VAS	Total	Breathlessness and activity	Chest symptoms	Psychological impact
	Parameter	Estimate	Estimate	Estimate	Estimate	Estimate	Estimate
Sex (Ref = Male)	Female	−0.016	2.63	−0.99	−1.39	− 0.90	− 1.49
Age		0.003**	−0.02	0.12	0.06	0.22	0.13
Education	Basic	−0.05*	−5.44	−1.85	−4.47	− 1.66	− 0.84
(Ref = higher)	Secondary	0.03	−0.65	0.24	0.16	2.86	0.14
Employment	Full-time	0.11**	6.05	3.78	5.85	7.19	2.31
(Ref = retired)	Part-time	0.07	7.9	3.39	7.26	2.13	3.27
	Not employed	−0.02	−3.38	−0.23	−1.03	−3.49	−0.19
Clinic (Ref = GH)	Heidelberg	0.03	1.86	2.28	3.61	4.25	3.05
Smoking status (Ref = smoker)	Never smoker	0.03	0.75	6.00	3.01	6.45	9.53*
Smoking status (Ref = smoker)	Former Smoker	−0.02	0.45	−2.69	−4.52	−4.71	−2.59
FVC % pred		0.002***	0.19*	0.15**	0.28***	0.27**	0.16**
DLCO % pred		−0.0004	−0.06	0.07	0.20*	−0.004	0.06
Disease Subtype (Ref = other)	IPF	0.07*	8.39*	3.51	7.85*	3.62	2.71
	Sarcoidosis	−0.001	−0.49	− 0.90	−4.34	− 5.71	0.67
	HP	0.02	0.73	3.33	3.29	4.89	4.43
	Other IIPs¹	0.09*	8.78	4.70	5.48	1.16	7.29*
Comorbidity sum score		−0.03***	−2.72**	−1.51**	−3.06***	− 2.68**	− 1.44*

Values depicted are the beta estimates of regression coefficients. Abbreviations: IPF-idiopathic pulmonary fibrosis, HP-Hypersensitivity pnemonitis, GH-Großhansdorf. ¹including: non-specific interstitial pneumonia, desquamative interstitial pneumonia, cryptogenetic organizing pneumonia, lymphocytic interstitial pneumonia,respiratory bronchiolitis-associated interstitial lung disease, pleuropulmonary fibroelastosis, and acute interstitial pneumonia. *p ≤ 0.05, **p ≤ 0.01, ***p ≤ 0.001

ISSN: 1465-993X