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Fig. 5 | Respiratory Research

Fig. 5

From: Knockdown of annexin A5 restores gefitinib sensitivity by promoting G2/M cell cycle arrest

Fig. 5

Knockdown ANXA5 induces G2/M arrest by suppressing polo-like kinase 1. a Whole-genome human cDNA array screening. b mRNA and protein levels of EGFR, polo-like kinase 1 (c), cyclin-dependent kinase 1 (d), topoisomerase 2α (e), and BIRC5 (f) were determined by qPCR and western blot in PC9R cells expressing shANXA5 or negative control shRNA (shNEG). g Proliferation of PC9R cells co-transfected with EGFR (EGFR-over), shANXA5, and shNEG, as determined by CCK8. h Proliferation of PC9R cells transfected with shANXA5 and shNEG and treated with the BIRC5 inhibitor YM155, as determined by CCK8. *, P < 0.05 vs. negative control

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