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Fig. 1 | Respiratory Research

Fig. 1

From: Knockdown of annexin A5 restores gefitinib sensitivity by promoting G2/M cell cycle arrest

Fig. 1

ANXA5 is upregulated in gefitinib-resistant cells, and confers gefitinib resistance. a-c ANXA5 expression in PC9R and H4006R cells, as assessed by qPCR and western blot. d-f qPCR and western blot of ANXA5 expression in PC9R and H4006R cells expressing shANXA5 or negative control shRNA (shNEG). g-h Morphology of PC9R and H4006R cells expressing shANXA5 or shNEG and cultured in 1 μM gefitinib. i-j Viability of PC9R and H4006R cells expressing shANXA5 or shNEG and treated with different concentrations of gefitinib, as determined by CCK8 assay. Data are representative of at least three similar experiments. *, P < 0.05 vs. negative control

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