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Table 3 Thirty- and 90-day mortality risk, expressed as hazard ratios, by suPAR levels, entered as either continuous (log-transformed) or in quartiles, at index admission in patients with AE COPD, any COPD and Respiratory failure due to COPD

From: Soluble urokinase plasminogen activator receptor predicts mortality in exacerbated COPD

Outcome

Analysis

Variable

AECOPD (n = 717)

any COPD (n = 2573)

Respiratory failure (n = 265)

HR (95% CI)

p-value

HR (95% CI)

p-value

HR (95% CI)

p-value

30-day mortalityb

Univariate

Continuous

2.2 (1.5–3.2)

< 0.0001

2.5 (2.1–2.9)

< 0.0001

1.5 (1.0–2.1)

0.04

1.quartile

1

 

1

 

1

 

2.quartile

1.6 (0.5–4.9)

0.42

2.0 (1.1–3.5)

0.02

1.2 (0.6–2.7)

0.62

3.quartile

3.3 (1.2–9.0)

0.02

3.3 (1.9–5.6)

< 0.0001

1.1 (0.5–2.4)

0.82

4.quartile

3.7 (1.4–10.1)

0.01

7.6 (4.6–12-6)

< 0.0001

1.8 (0.9–3.7)

0.12

Multivariatea

Continuous

1.8 (1.2–2.8)

0.005

2.0 (1.7–2.4)

< 0.0001

1.3 (0.8–2.0)

0.23

1.quartile

1

 

1

 

1

 

2.quartile

1.2 (0.4–3.8)

0.73

1.5 (0.8–2.6)

0.20

1.2 (0.5–2.7)

0.66

3.quartile

2.3 (0.8–6.6)

0.11

1.8 (1.1–3.2)

0.03

0.8 (0.4–1.9)

0.65

4.quartile

2.0 (0.7–5.7)

0.20

3.4 (2.0–5.9)

< 0.0001

1.3 (0.6–2.8)

0.50

90-day mortalityc

Univariate

Continuous

2.5 (2.0–3.3)

< 0.0001

2.3 (2.1–2.6)

< 0.0001

1.5 (1.1–2.2)

0.01

1.quartile

1

 

1

 

1

 

2.quartile

2.1 (0.9–5.3)

0.1

1.9 (1.2–2.9)

0.007

1.1 (0.6–2.4)

0.72

3.quartile

4.9 (2.2–11-1)

0.0001

3.6 (2.4–5.4)

< 0.0001

1.0 (0.5–2.1)

0.98

4.quartile

7.1 (3.2–15.8)

< 0.0001

7.3 (4.9–10.8)

< 0.0001

1.6 (0.8–3.1)

0.20

Multivariatea

Continuous

2.2 (1.6–2.9)

< 0.0001

2.3 (2.1–2.6)

< 0.0001

1.4 (1.0–2.1)

0.06

1.quartile

1

 

1

 

1

 

2.quartile

1.8 (0.7–4.5)

0.19

1.5 (0.8–2.6)

0.20

1.1 (0.6–2.4)

0.72

3.quartile

3.9 (1.7–8.9)

0.001

1.8 (1.1–3.2)

0.03

1.0 (0.5–2.1)

0.98

4.quartile

4.3 (1.9–9.9)

0.0005

3.4 (2.0–5.9)

< 0.0001

1.6 (0.8–3.1)

0.20

  1. aAdjusted for age, sex, Charlson score and CRP
  2. bNumber of events were 45, 227 and 52 in AECOPD, any COPD and Respiratory failure, respectively
  3. cNumber of events were 93, 358 and 67 in AECOPD, any COPD and Respiratory failure, respectively