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Fig. 3 | Respiratory Research

Fig. 3

From: Modelling the asthma phenotype: impact of cigarette smoke exposure

Fig. 3

Effect of gold standard asthma treatments on a CS co-exposure rat model of allergic asthma. Sensitised male Brown Norway rats were challenged with an aerosol of saline or OVA for 30 min. Rats were co-exposed to room air or CS for eight days and dosed with vehicle (1 ml/kg, intratracheal, i.t.), budesonide (3 mg/kg, i.t), Olodaterol (1 mg/kg, i.t.) or glycopyrrolate (1 mg/kg, i.t.) one hour prior to and 30 min after antigen challenge. Changes in lung function were assessed from 1 h after the end of challenge for 5 h. Data are represented as mean ± S.E.M. for n = 8 animals in each group. a: Glucocortoid, b: LABA and c: LAMA

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