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Fig. 2 | Respiratory Research

Fig. 2

From: Modelling the asthma phenotype: impact of cigarette smoke exposure

Fig. 2

Effect of glucocorticoid treatment on a CS co-exposure rat model of allergic asthma. Sensitised male Brown Norway rats were challenged with an aerosol of saline or OVA for 30 min. Rats were co-exposed to room air or CS for eight days and dosed with vehicle (1 ml/kg, intratracheal) or budesonide (3 mg/kg, i.t) one hour prior to and 30 min after antigen challenge. BALF was collected the following day and the numbers of white cells assessed. Data are represented as mean ± S.E.M. for n = 8 animals in each group. a: Eosinophil number, b: neutrophil number and c: lymphocyte number. The statistical significance of the response to antigen and/or CS was determined using Mann-Whitney and denoted with # (P < 0.05). The significance of the impact of budesonide was determined using Mann-Whitney and denoted with * (P < 0.05)

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