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Fig. 1 | Respiratory Research

Fig. 1

From: Modelling the asthma phenotype: impact of cigarette smoke exposure

Fig. 1

Effect of CS co-exposure on a rat model of allergic asthma. Sensitised male Brown Norway rats were challenged with an aerosol of saline or OVA for 30 min. Rats were co-exposed to room air or CS (twice a day) for eight days. Changes in lung function (Penh) were assessed from 1 h after the end of challenge for 5 h. BALF was collected the following day and the numbers of white cells assessed. Data are represented as mean ± S.E.M. for n = 8 animals in each group. a: LAR, b: neutrophil number, c: Eosinophil number and d: lymphocyte number. The statistical significance of the response to antigen and/or CS was determined using a Mann-Whitney U test and denoted with # (P < 0.05)

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