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Table 5 Correlations between immunohistological findings and lung function parameters (n = 33)

From: Immunohistological features related to functional impairment in lymphangioleiomyomatosis

  Density of nodules Density of cysts VEGF-D MMP-9 mTOR D2-40
FEV1 (%predicted) r = −0.51
p = 0.003
r = −0.58
p < 0.001
r = − 0.60
p < 0.001
r = − 0.62
p < 0.001
r = − 0.55
p = 0.002
ns
DLco (%predicted) r = − 0.68
p < 0.001
r = − 0.53
p = 0.003
r = − 0.51
p = 0.004
r = − 0.66
p < 0.001
ns r = − 0.48
p = 0.008
  1. ns not significant, DL CO diffusion capacity for carbon monoxide, D2-40 podoplanin, FEV 1 forced expiratory volume in the first second, MMP-9 metalloproteinase 9, mTOR mammalian target of rapamycin, VEGF-D vascular endothelial growth factor-D