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Table 4 Comparison between RTL in diseased and normal lungs, adjusted for lung age, BMI and sex

From: The aging lung: tissue telomere shortening in health and disease

Comparison Estimate % change 95% CI p-value
CF vs normal 0.0090 2.09 −9.20 - 14.77 0.73
COPD vs normal 0.032 7.67 −2.93 – 19.44 0.16
cHP vs normal −0.14 −27.97 −34.63 - -20.64 < 0.0001
BOS vs normal −0.069 −14.62 −23.53 - -4.69 0.0051
RAS vs normal −0.048 −10.43 −18.91 - -1.06 0.030
  1. Multivariate mixed linear model comparing diseased lungs with normal lungs with lung as random effect, adjusted for lung age, BMI and sex. Estimates are presented as percentage change (95% CI) in average RTL per group compared to normal lungs
  2. RTL relative telomere length, 95% CI 95% confidence interval, CF cystic fibrosis, COPD chronic obstructive pulmonary disease, cHP chronic hypersensitivity pneumonitis, BOS bronchiolitis obliterans syndrome, RAS restrictive allograft syndrome, vs versus
  3. p-value < 0.05 is captured in bold