The aging lung: tissue telomere shortening in health and disease

Respiratory Research

Table 4 Comparison between RTL in diseased and normal lungs, adjusted for lung age, BMI and sex

Comparison	Estimate	% change	95% CI	p-value
CF vs normal	0.0090	2.09	−9.20 - 14.77	0.73
COPD vs normal	0.032	7.67	−2.93 – 19.44	0.16
cHP vs normal	−0.14	−27.97	−34.63 - -20.64	< 0.0001
BOS vs normal	−0.069	−14.62	−23.53 - -4.69	0.0051
RAS vs normal	−0.048	−10.43	−18.91 - -1.06	0.030

Multivariate mixed linear model comparing diseased lungs with normal lungs with lung as random effect, adjusted for lung age, BMI and sex. Estimates are presented as percentage change (95% CI) in average RTL per group compared to normal lungs
RTL relative telomere length, 95% CI 95% confidence interval, CF cystic fibrosis, COPD chronic obstructive pulmonary disease, cHP chronic hypersensitivity pneumonitis, BOS bronchiolitis obliterans syndrome, RAS restrictive allograft syndrome, vs versus
p-value < 0.05 is captured in bold

ISSN: 1465-993X