Comparison | Estimate | % change | 95% CI | p-value |
---|
CF vs normal | 0.0090 | 2.09 | −9.20 - 14.77 | 0.73 |
COPD vs normal | 0.032 | 7.67 | −2.93 – 19.44 | 0.16 |
cHP vs normal | −0.14 | −27.97 | −34.63 - -20.64 |
< 0.0001
|
BOS vs normal | −0.069 | −14.62 | −23.53 - -4.69 |
0.0051
|
RAS vs normal | −0.048 | −10.43 | −18.91 - -1.06 |
0.030
|
- Multivariate mixed linear model comparing diseased lungs with normal lungs with lung as random effect, adjusted for lung age, BMI and sex. Estimates are presented as percentage change (95% CI) in average RTL per group compared to normal lungs
- RTL relative telomere length, 95% CI 95% confidence interval, CF cystic fibrosis, COPD chronic obstructive pulmonary disease, cHP chronic hypersensitivity pneumonitis, BOS bronchiolitis obliterans syndrome, RAS restrictive allograft syndrome, vs versus
- p-value < 0.05 is captured in bold