Skip to main content

Advertisement

Springer Nature is making SARS-CoV-2 and COVID-19 research free. View research | View latest news | Sign up for updates

Table 2 Relation between RTL and lung age in normal and diseased lung tissue

From: The aging lung: tissue telomere shortening in health and disease

Group Estimate % change 95% CI p-value
NORMAL −0.0039 −0.90 −1.26 - -0.54 0.0001
CF −0.0045 −1.04 −2.21 - 0.16 0.090
COPD 0.015 3.41 1.36 - 5.49 0.0016
cHP −0.0024 − 0.55 −4.98 - 4.10 0.81
BOS −0.0033 −0.76 −1.41 - -1.41 0.022
RAS −0.0021 −0.47 − 0.88 - -0.06 0.027
  1. Mixed linear models were used to measure the association between tissue RTL and lung age, with the lung as random effect, adjusted for sex and BMI. Estimates are presented as percentage change (95% CI) in average RTL for each 1-year increase in lung age
  2. RTL relative telomere length, 95% CI 95% confidence interval, CF cystic fibrosis, COPD chronic obstructive pulmonary disease, cHP chronic hypersensitivity pneumonitis, BOS bronchiolitis obliterans syndrome, RAS restrictive allograft syndrome
  3. p-value < 0.05 is captured in bold