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Table 1 Demographic and clinical characteristics of lungs

From: The aging lung: tissue telomere shortening in health and disease

 

NORMAL

CF

COPD

cHP

BOS

RAS

Subjects, n

13

12

11

9

11

14

Lung age, years

48 (20)

23 (7)*

60 (3)

58 (10)

27 (24)

46 (23)

Lung age, range

16-72

19-33

48-61

36-61

16-48

9-61

Male, n (%)

10 (77)

5 (42)

5 (45)

4 (44)

5 (45)

8 (57)

Male donor, n (%)

NA

NA

NA

NA

5 (45)

8 (57)

Patient height, cm

175 (15)

162 (18)

163 (22)

166 (19)

168 (12)

168 (17)

Patient weight, kg

80 (25)

46 (14)***

60 (17)

74 (9)

51 (21)**

60 (21)*

BMI, kg/m2

25 (4)

18 (2)***

21 (8)

27 (4)

18 (5)**

19 (6)**

FEV1, L

NA

0.8 (0.4)

0.8 (0.5)

1.1 (0.8)

0.6 (0.3)

0.9 (0.5)

FEV1, % predicted

NA

23 (10)

31 (11)

49 (21)

20 (3)

26 (12)

FVC, L

NA

1.6 (0.8)

2.0 (0.4)

1.3 (0.9)

1.5 (1)

1.4 (0.6)

FVC, % predicted

NA

45 (15)

66 (33)

38 (20)

46 (20)

33 (13)

FEV1/FVC

NA

0.5 (0.1)

0.4 (0.1)

0.9 (0.2)

0.4 (0.1)

0.7 (0.3)

DLco, % predicted

NA

38 (33)a

33 (14)

30 (7)

40 (18)b

35 (8)c

  1. a, b, c respectively 6, 1 and 7 missing values. Results are given as n (%) or median (IQR). % predicted of FEV1 and FVC was based on ECSC equations before 2012 [45] and on GLI equations from 2012 onwards [46]. ATS recommendations were used for equations of DLCO reference [47]. Significant difference with the normal lungs is indicated with *p < 0.05, **p < 0.01 and ***p < 0.001
  2. CF cystic fibrosis, COPD chronic obstructive pulmonary disease, cHP chronic hypersensitivity pneumonitis, BOS bronchiolitis obliterans syndrome, RAS restrictive allograft syndrome, NA not applicable, BMI body mass index, FEV1 forced expiratory volume in 1 s, FVC forced vital capacity, FEV1/FVC tiffeneau index, DLco diffusion capacity of the lung for carbon monoxide