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Table 1 Demographic and clinical characteristics of lungs

From: The aging lung: tissue telomere shortening in health and disease

  NORMAL CF COPD cHP BOS RAS
Subjects, n 13 12 11 9 11 14
Lung age, years 48 (20) 23 (7)* 60 (3) 58 (10) 27 (24) 46 (23)
Lung age, range 16-72 19-33 48-61 36-61 16-48 9-61
Male, n (%) 10 (77) 5 (42) 5 (45) 4 (44) 5 (45) 8 (57)
Male donor, n (%) NA NA NA NA 5 (45) 8 (57)
Patient height, cm 175 (15) 162 (18) 163 (22) 166 (19) 168 (12) 168 (17)
Patient weight, kg 80 (25) 46 (14)*** 60 (17) 74 (9) 51 (21)** 60 (21)*
BMI, kg/m2 25 (4) 18 (2)*** 21 (8) 27 (4) 18 (5)** 19 (6)**
FEV1, L NA 0.8 (0.4) 0.8 (0.5) 1.1 (0.8) 0.6 (0.3) 0.9 (0.5)
FEV1, % predicted NA 23 (10) 31 (11) 49 (21) 20 (3) 26 (12)
FVC, L NA 1.6 (0.8) 2.0 (0.4) 1.3 (0.9) 1.5 (1) 1.4 (0.6)
FVC, % predicted NA 45 (15) 66 (33) 38 (20) 46 (20) 33 (13)
FEV1/FVC NA 0.5 (0.1) 0.4 (0.1) 0.9 (0.2) 0.4 (0.1) 0.7 (0.3)
DLco, % predicted NA 38 (33)a 33 (14) 30 (7) 40 (18)b 35 (8)c
  1. a, b, c respectively 6, 1 and 7 missing values. Results are given as n (%) or median (IQR). % predicted of FEV1 and FVC was based on ECSC equations before 2012 [45] and on GLI equations from 2012 onwards [46]. ATS recommendations were used for equations of DLCO reference [47]. Significant difference with the normal lungs is indicated with *p < 0.05, **p < 0.01 and ***p < 0.001
  2. CF cystic fibrosis, COPD chronic obstructive pulmonary disease, cHP chronic hypersensitivity pneumonitis, BOS bronchiolitis obliterans syndrome, RAS restrictive allograft syndrome, NA not applicable, BMI body mass index, FEV1 forced expiratory volume in 1 s, FVC forced vital capacity, FEV1/FVC tiffeneau index, DLco diffusion capacity of the lung for carbon monoxide