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Table 3 Types of EGFR and KRAS mutations and frequency of VTE

From: Association between oncogenic status and risk of venous thromboembolism in patients with non-small cell lung cancer

Mutation type Number VTE
(n = 306) (%) (n = 32) (%)
EGFR exon 18 mutation only 3 (1.0) 0 (0.0)
EGFR exon 19 deletion only 106 (34.6) 9 (28.1)
EGFR exon 20 T790 M only 0 (0.0) 0 (0.0)
EGFR exon 20 S768I only 4 (1.3) 0 (0.0)
EGFR exon 20 insertion only 11 (3.6) 0 (0.0)
EGFR exon 21 L858R only 106 (34.6) 12 (37.5)
EGFR exon 21 L861Q only 7 (2.3) 0 (0.0)
EGFR exon 18 + exon 21 L861Q 1 (0.3) 0 (0.0)
EGFR exon 18 + exon 20 S768I 2 (0.6) 1 (3.1)
EGFR exon 19 + exon 21 L861Q 1 (0.3) 0 (0.0)
EGFR exon 19 + exon 20 T790 M 1 (0.3) 0 (0.0)
EGFR exon 20 T790 M + exon 21 L858R 1 (0.3) 0 (0.0)
EGFR exon 20 S768I + exon 21 L858R 1 (0.3) 0 (0.0)
KRAS codon G12C(34G > T) only 19 (6.2) 5 (15.6)
KRAS codon G12S(34G > A) only 2 (0.6) 2 (6.3)
KRAS codon G12R(34G > C) only 5 (1.6) 0 (0.0)
KRAS codon G12 V(35G > T) only 14 (4.6) 3 (9.4)
KRAS codon G12D(35G > A) only 12 (3.9) 0 (0.0)
KRAS codon G12A(35G > C) only 9 (2.9) 0 (0.0)
KRAS codon G13D(38G > A) only 0 (0.0) 0 (0.0)
KRAS codon G12R(34G > C) + codon G12D(35G > A) 1 (0.3) 0 (0.0)
  1. Abbreviations: EGFR epidermal growth factor receptor, KRAS kitten rat sarcoma