Fig. 9
From: Effects and molecular mechanisms of intrauterine infection/inflammation on lung development
mRNA expression of IL-1β, IL-6, TNF-α and NLRP3. a: Analysis of IL-1β expression in the fetal and neonatal rat lung tissues showed significant mRNA up-regulation at E17, E19, E21 d and P1, P3, P7 in intrauterine infection group, relative to control. b: qRT-PCR analysis for the fetal and neonatal rats lung tissues showed significantly increased expression of IL-6 at E17, E21and P1 in intrauterine infection group, relative to control. c: Analysis of TNF-α expression in the fetal and neonatal rat lung tissues showed significant mRNA up-regulation at E17, E19, E21 and P1, P3 in intrauterine infection group, relative to control. d: Significant increases in NLRP3 (at E17, E19, E21 and P1, P3, P14) mRNA expression were identified in intrauterine infection group compared to the control group. The mRNA quantitation was calculated by using the ΔCt method and higher ΔCt means lower expression levels. *P < 0.05; **P < 0.01, vs. control group