Table 2 Clinical variables and biomarkers as predictors of mortality following acute exacerbations of IIP

 Age

1.059 (1.007–1.113)

0.025*

1.045 (0.952–1.147)

0.357

 FVC %pred

0.985 (0.961–1.008)

0.195

1.023 (0.991–1.057)

0.164

 Time from diagnosis to admission, months (median IQR)

1.010 (0.999–1.020)

0.066

1.013 (0.991–1.034)

0.255

 Treatment duration from admission, days (median IQR)

0.961 (0.915–1.009)

0.110

0.940 (0.856–1.031)

0.187

 Female gender

2.420 (1.166–5.025)

0.018*

NA

NA

 Ex smoker

0.631 (0.312–1.279)

0.202

1.120 (0.248–5.054)

0.883

 Current smoker

0.000 (5× e^− 191 - 963× e¹⁷⁷)

0.957

NA

NA

 BGM

1.047 (0.759–1.442)

0.783

0.966 (0.562–1.662)

0.901

 C1M

1.277 (0.946–1.714)

0.108

1.449 (0.911–2.316)

0.116

 C3M

1.010 (0.722–1.412)

0.955

0.878 (0.486–1.585)

0.665

 C4M

1.214 (0.879–1.675)

0.237

1.115 (0.681–1.831)

0.663

 C6M

1.042 (0.774–1.406)

0.785

1.160 (0.702–1.915)

0.564

 CRPM

0.959 (0.707–1.304)

0.792

0.939 (0.538–1.638)

0.824

 ELM7

1.101 (0.798–1.518)

0.559

0.954 (0.559–1.628)

0.862

 VCANM

0.636 (0.432–0.937)

0.022*

0.828 (0.446–1.538)

0.551