Fig. 1

Serum biomarker levels at stability and acute exacerbations. Biomarker levels are shown in the total IIP population (left) and the IPF subpopulation (right) at stability (S, white) and at acute exacerbation (AE, grey). Data are shown as Tukey box-plots where the box represents the interquartile range (IQR) with the median shown as a line, whiskers represent 1.5 times the IQR, and circles show data points outside this range. Dotted line indicate reference biomarker level of a healthy population. Statistical significance was determined by Mann-Whitney test (*p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001)