Fig. 1

Acute and chronic right ventricle hemodynamics and remodeling in Antimycin A-treated rats. RV systolic (a) pressure in untreated Controls and acutely AA-treated rats 30 min, 1 and 3 days after AA (0.35 mg/kg) injection show the acute and reversible effect of one dose of AA on pulmonary pressure (left panel). Right panel represents RV systolic pressure in chronically treated rats. 6, 12 and 24 days after AA injection show a progressive chronic pulmonary vasoconstriction and RV dysfunction. There was no evidence of RV hypertrophy during the first 24 days of AA treatment (b). End diastolic RV pressure indicates significant elevation at day 12 and 24 (c). There is no indication of LV hypertrophy (d). AA (10 μM) treatment of PAEC (e) or SMC (f) results in a 6-fold decrease in OCR. Decrease in OCR was accompanied with an increase in glycolysis as indicated by ECAR. Data are mean ± SEM, N = 4–13 per group. *P < 0.05 vs. Control/Vehicle in 1-way ANOVA or t-test for two groups