Table 3 Magnitude of the pharmacological interaction between BDP and FF administered at 100:6 combination-ratio in non-sensitized and passively sensitized human medium and small airways (PCLS)
Medium bronchi | Small airways | |||||||
|---|---|---|---|---|---|---|---|---|
Non-sensitized | Passively sensitized | Non-sensitized | Passively sensitized | |||||
Relaxant effect (% Emax) | Combination Index | Interaction magnitude | Combination Index | Interaction magnitude | Combination Index | Interaction magnitude | Combination Index | Interaction magnitude |
15 | 0.47 | +++ | 0.51 | +++ | 0.47 | +++ | 0.06 | +++++ |
25 | 0.34 | +++ | 0.38 | +++ | 0.29 | ++++ | 0.08 | +++++ |
50 | 0.22 | ++++ | 0.26 | ++++ | 0.12 | ++++ | 0.15 | ++++ |
75 | 0.15 | ++++ | 0.20 | ++++ | 0.05 | +++++ | 0.28 | ++++ |
90 | 0.10 | ++++ | 0.14 | ++++ | 0.02 | +++++ | 0.52 | +++ |