Parameter | Pre-matching | Post matching | ||||
---|---|---|---|---|---|---|
ICS (N = 1745) | Non-ICS (N = 2264) | P value | ICS (N = 1739) | Non-ICS (N = 1739) | P value | |
Female, n (%) | 679 (38.9) | 906 (40.0) | 0.494 | 676 (38.9) | 697 (40.1) | 0.480 |
Mean age, years (SD) | 67.6 (10.3) | 68.0 (10.3) | 0.237 | 67.6 (10.3) | 67.9 (10.2) | 0.480 |
Mean BMI, kg/m2 (SD) | 27 (5.8) | 27 (5.8) | 0.4189 | 27 (5.8) | 27 (6.0) | 0.3166 |
Mean FEV1 predicted, % (SD) | 57 (19.4) | 61 (18.5) | < 0.001 | 57 (19.4) | 61 (18.5) | < 0.001 |
Age category, n (%) | ||||||
40–44 years | 29 (1.7) | 26 (1.1) | 0.321 | 27 (1.6) | 21 (1.2) | 0.143 |
45–54 years | 171 (9.8) | 201 (8.9) | 171 (9.8) | 153 (8.8) | ||
55–64 years | 455 (26.1) | 618 (27.3) | 454 (26.1) | 479 (27.5) | ||
65–74 years | 628 (36.0) | 777 (34.3) | 626 (36.0) | 603 (34.7) | ||
75–80 years | 275 (15.8) | 369 (16.3) | 274 (15.8) | 270 (15.5) | ||
> 80 years | 187 (10.7) | 273 (12.1) | 187 (10.8) | 213 (12.2) | ||
BMI category, n (%) | ||||||
Underweight (< 18.5) | 79 (4.5) | 78 (3.4) | 0.076 | 79 (4.5) | 55 (3.2) | 0.235 |
Normal (18.5–24.9) | 512 (29.3) | 662 (29.2) | 512 (29.4) | 509 (29.3) | ||
Overweight (25–29.9) | 436 (25.0) | 629 (27.8) | 434 (25.0) | 484 (27.8) | ||
Obese (30–39.9) | 361 (20.7) | 418 (18.5) | 358 (20.6) | 325 (18.7) | ||
Severely obese (≥ 40) | 26 (1.5) | 47 (2.1) | 26 (1.5) | 39 (2.2) | ||
Missing | 331 (19.0) | 430 (19.0) | 330 (19.0) | 327 (18.8) | ||
Smoking status, n (%) | ||||||
Current | 726 (41.6) | 994 (43.9) | 0.097 | 725 (41.7) | 750 (43.1) | 0.513 |
Non-smoker/never smoked | 90 (5.2) | 85 (3.8) | 88 (5.1) | 67 (3.9) | ||
Ex-smoker | 773 (44.3) | 972 (42.9) | 770 (44.3) | 761 (43.8) | ||
Missing | 156 (8.9) | 213 (9.4) | 156 (9.0) | 161 (9.3) | ||
IMD quintile, n (%) | ||||||
I | 292 (16.7) | 322 (14.2) | 0.175 | 291 (16.7) | 249 (14.3) | 0.254 |
II | 326 (18.7) | 411 (18.2) | 325 (18.7) | 313 (18.0) | ||
III | 336 (19.3) | 438 (19.3) | 334 (19.2) | 352 (20.2) | ||
IV | 390 (22.3) | 526 (23.2) | 388 (22.3) | 387 (22.3) | ||
V | 399 (22.9) | 565 (23.2) | 399 (22.9) | 436 (25.1) | ||
2017 GOLD classification, n (%) | ||||||
GOLD A | 1044 (59.8) | 1479 (65.3) | < 0.001 | 1044 (60.0) | 1068 (61.4) | 0.356 |
GOLD B | 701 (40.2) | 785 (34.7) | 695 (40.0) | 671 (38.6) | ||
Comorbidities, n (%) | ||||||
Eosinophilia (> 0.4 × 109/L) | 119 (6.8) | 153 (6.8) | 0.933 | 119 (6.8) | 127 (7.3) | 0.942 |
Eosinophilia (> 0.3 × 109/L) | 326 (18.7) | 399 (17.6) | 0.683 | 326 (18.7) | 307 (17.7) | 0.822 |
Eosinophilia (read code) | < 5 (−) | < 5 (−) | 0.214 | < 5 (−) | < 5 (−) | 0.942 |
Asthma diagnosed > 1 year prior | 310 (17.8) | 304 (13.4) | < 0.001 | 304 (17.5) | 273 (15.7) | 0.093 |
Type II diabetes | 271 (15.5) | 339 (15.0) | 0.627 | 270 (15.5) | 267 (15.4) | 0.888 |
Osteoporosis/osteopenia | 227 (13.0) | 286 (12.6) | 0.724 | 227 (13.1) | 225 (12.9) | 0.921 |
Stroke | 118 (6.8) | 144 (6.4) | 0.610 | 117 (6.7) | 115 (6.6) | 0.893 |
Myocardial infarction | 166 (9.5) | 238 (10.5) | 0.297 | 166 (9.5) | 166 (9.5) | 1.000 |
Pneumonia | 357 (20.5) | 443 (19.6) | 0.484 | 356 (20.5) | 356 (20.5) | 1.000 |
Prior exacerbations | 711 (40.7) | 895 (39.5) | 0.437 | 709 (40.8) | 705 (40.5) | 0.890 |