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Fig. 2 | Respiratory Research

Fig. 2

From: Acute lung injury by gastric fluid instillation: activation of myofibroblast apoptosis during injury resolution

Fig. 2

Resolution of lung injury after a single instillation of gastric fluid. Light microscopy (hematoxylin-eosin, Masson’s trichrome and α-SMA immunohistochemistry) of rat lung at days 4, 7 and 14 after a single orotracheal instillation of gastric fluid. With H-E (upper panel), intra-alveolar buds of granulation tissue (Masson bodies), characteristic of OP at days 4 and 7 are observed. Foreign body giant cells, either isolated or forming granulomas are also seen. This pattern is no longer present at day 14. With trichrome stain (middle panel) and α-SMA immunostaining (lower panel) abundant collagen fibers are seen intermixed with myofibroblasts in Masson bodies at days 4 and 7. These findings are no longer present at day 14. Original magnification: 200X

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Respiratory Research

ISSN: 1465-993X

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