Table 2 Genetic loci associated with smoking behaviour in the Lung Health Study
From: The genetics of smoking in individuals with chronic obstructive pulmonary disease
Phenotype | SNP | Chr | Gene(s) | Position (hg19) | Alleles (REF/ALT) | MAF | Imputation r2 | beta | SE | P value | % Variance |
|---|---|---|---|---|---|---|---|---|---|---|---|
Cotinine | rs10023464 | 4 | UGT2B10 | 69,659,738 | C/T | 9.8% | 0.995 | 0.25 | 0.04 | 1.27e-11 | 1.1% |
Cotinine | rs9788721 | 15 | CHRNA3/5 | 78,802,869 | C/T | 39.5% | 0.989 | −0.12 | 0.02 | 3.49e-7 | 0.6% |
eCO | rs546764 | 3 | CEP70 | 138,294,336 | T/G | 2.8% | 0.844 | 0.39 | 0.07 | 7.76e-8 | 0.9% |
eCO | rs140706189 | 14 | SIX1/4/6, MNAT1 | 61,151,425 | T/G | 1.7% | 0.827 | −0.49 | 0.09 | 6.31e-8 | 0.9% |
eCO | rs12914385 | 15 | CHRNA3/5 | 78,898,723 | C/T | 43% | 1.000 | 0.12 | 0.02 | 2.38e-8 | 1.2% |
CPD | rs1412076 | 9 | NTNG2/ SETX | 135,032,890 | A/G | 37.6% | 0.999 | 0.10 | 0.02 | 2.24e-7 | 0.8% |
CPD | rs9599114 | 13 | PCDH9 | 66,987,131 | T/C | 41.7% | 0.957 | 0.11 | 0.02 | 7.94e-8 | 0.8% |
Cessation | rs212420 | 7 | ATXN7L1/ CDHR3 | 105,496,412 | C/G | 6.7% | 0.992 | −0.60 | 0.11 | 1.50e-7 | n/a |
Cessation | rs207675 | 10 | KCNMA1 | 79,154,537 | T/C | 33.6% | 0..988 | −0.35 | 0.06 | 5.95e-8 | n/a |