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Table 1 Study design and clinical characteristics of included studies

From: Effect of continuous positive airway pressure on long-term cardiovascular outcomes in patients with coronary artery disease and obstructive sleep apnea: a systematic review and meta-analysis

Source

Study design, location, years

Number of participants

Main inclusion criteria

Mean age (Years)

Male (%)

Mean BMI (kg/m2)

Mean AHI (events/h)

Mean ESS (points)

OSA assessment

Milleron et al., 2004 [7]

Prospective cohort, single-center in France, 1991–1999

54

AHI ≥ 15

57.3

98.1

28.3

31.2

NR

Polysomnography

Cassar et al., 2007 [8]

Retrospective cohort, single-center in US, 1992–2004

371

AHI ≥ 15

64.0

87.6

34.1

44.2

NR

Polysomnography

Garcia-Rio et al., 2013 [9]

Prospective cohort, single-center in Spain, 2003–2005

123

AHI ≥ 5

58.0

86.2

27.3

21.7

8.5

Polysomnography

Capodanno et al., 2014 [10]

Prospective cohort, single-center in Italy, 2008

129

AHI ≥ 15

68.3

80.6

27.3

22.4

7

Portable diagnostic device

Nakashima et al., 2015 [11]

Prospective cohort, single-center in Japan, 2003–2009

95

AHI ≥ 20

71.0a

77.0a

NR

NR

NR

Polysomnography

Wu et al., 2015 [12]

Retrospective cohort, single-center in China, 2002–2012

295

AHI ≥ 15

55.1

84.4

29.7

42.8

NR

Polysomnography 72.1%, Portable diagnostic device 27.9%

Leão et al., 2016 [13]

Prospective cohort, single-center in Portugal, NR

46

AHI ≥ 5

63.5

82.6

27.8

30.6

8.8

Portable diagnostic device

Huang et al., 2015 [14]

RCT, parallel, single-center in China, 2009–2012

73

AHI ≥ 15, ESS < 15

62.4

82.2

27.7

28.5

8.8

Polysomnography

Peker et al., 2016 [15]

RCT, parallel, single-center in Sweden, 2005–2010

244

AHI ≥ 15, ESS < 10

66.0

84.1

28.5

28.8

5.5

Polysomnography

  1. AHI apnea-hypopnea index, BMI body mass index, ESS Epworth Sleepiness Scale, NR not reported, OSA obstructive sleep apnea, RCT randomized controlled trial
  2. aIndicate values in patients with AHI ≥ 15