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Table 1 Information on smokers and non-smokers with normal lung function, included in the study

From: Expression of MATE1, P-gp, OCTN1 and OCTN2, in epithelial and immune cells in the lung of COPD and healthy individuals

 

Non-Smokers

Smokers

p-value f

Total (n)

8

14

 

Males/Females (n)

3/5

3/11

 

Age

25 (20–34)

25 (19–50)

ns

Smoke status

Pack Years a

na

6 (1.8–24.5)

 

Cigarettes/day b

na

10 (7–30)

 

Spirometry

FVC c

102 (86–120)

108 (85–127)

ns

FEV d

101 (89–113)

104 (80–121)

ns

FEV1/FVC

83 (81–88)

78 (76–88)

ns

BAL

Recovery %

74 (64–80)

69 (50–77)

ns

Total cell count (10^6)

18.1 (10.1–24.4)

39.8 (15.9–154)

***

Cell conc. (10^6 cells /L)

94.0 (68.0–154.5)

257.8 (90.3–987.2)

**

Macrophages %

87.4 (66.6–96.0)

96.5 (92.0–99.0)

***

Macrophages (10^6 cells /L)

79.2 (60.5–101.6)

250.5 (83.1–949.7)

***

Lymphocytes %

10.5 (3.4–31.6)

1.9 (0.40–7.20)

***

Lymphocytes (10^6 cells /L)

8.75 (3.58–48.2)

6.40 (1.03–29.62)

ns

Neutrophils %

1.30 (0.20–6.40)

0.60 (0.20–2.40)

ns

Neutrophils (10^6 cells /L)

1.06 (0.14–5.98)

1.49 (0.34–8.95)

ns

Mastcells e

2.00 (0.00–10.0)

1.00 (0.00–6.00)

ns

  1. Numbers indicate median and range, if not otherwise indicated. Eosinophils and basophils were also counted and constituted ≤1.4% and ≤ 0.2%, respectively, of BAL cells in any subject, with no difference between smokers and non-smokers. a Pack years calculated as ([cigarettes smoked per day]/20 x [years smoking]). b Current smoking habits at time of bronchoscopy. c FVC: forced vital capacity, % of predicted. d FEV1: Forced expiratory volume in 1 s, % of predicted, e Calculated in 10 fields of view at 16× magnification. f Statistics calculated using Mann Whitney non-parametric test: ** < 0.01, *** < 0.001, ns: Not significant, na: Not applicable