Plasma YKL-40 and NGAL are useful in distinguishing ACO from asthma and COPD

Respiratory Research

Table 4 Multivariate stepwise regressions analysis of all subjects with each plasma biomarker as the dependent variable

YKL-40	β	T	p-value
FVC % pred,%	−0.314	−6.529	< 0.0001
FEV1%, pred	−0.301	−5.007	< 0.0001
% Change in FEV1, %	−1.497	−11.398	< 0.0001
FEV1/FVC,%	−0.325	−4.716	< 0.0001
Group, ACO vs. control	0.686	5.332	< 0.0001
Group, ACO vs. asthma	0.336	6.337	< 0.0001
Group, ACO vs. COPD	−1.014	−10.237	< 0.0001
NGAL
% LAA-950,%	0.22	5.191	< 0.0001
% Change in FEV1, %	−0.172	− 2.688	< 0.0001
Group, ACO vs. asthma	0.24	4.251	< 0.0001
Group, ACO vs. COPD	−0.419	−7.686	< 0.0001
TSLP
Group, ACO vs. control	0.374	8.262	< 0.0001

Abbreviations: YKL-40 chitinase-3-like protein 1, NGAL neutrophil gelatinase-associated lipocalin, TSLP Thymic stromal lymphopoietin, FVC forced vital capacity, FEV1 forced expiratory volume in 1 s, % pred % predicted, ΔFEV1 Change in FEV1, SGRQ St George’s Respiratory Questionnaire, %LAA-950 The percentage of the low attenuation area below − 950 HU

ISSN: 1465-993X