Plasma YKL-40 and NGAL are useful in distinguishing ACO from asthma and COPD

Respiratory Research

Table 3 Correlations between plasma biomarkers and subject characteristics, lung function, bronchodilator response and the emphysema percent

	YKL-40	NGAL	PTON	TSLP
Age,years	0.275***	0.297***	−0.043	0.252***
BMI,kg/m²	−0.16**	−0.094	0.043	0.203***
smoking,park-years	0.388***	0.353 ***	−0.041	0.231***
SGRQ scores	0.390***	0.359***	−0.164**	−0.042
FVC % pred	−0.588***	−0.253***	0.043	−0.267***
FEV1% pred	−0.673***	− 0.348***	0.01	− 0.258***
FEV1/FVC,%	−0.595***	− 0.401***	0.081	− 0.174***
Change in FEV1, ml	−0.321***	− 0.241***	0.087	0.203***
%Change in FEV1, %	− 0.241***	−0.192***	0.077	0.252***
% LAA-950,%	0.482***	0.377***	−0.101*	0.076
Blood eosinophil, 10⁸/L	0.093	−0.09	0.04	0.114*
Blood neuttrophil, 10⁹/L	0.09	0.227***	−0.104*	0.081
Serum creatinine,umol/L	0.055	0.191 ***	− 0.011	0.091

Note: *: p < 0.05; **: p < 0.01; ***: p < 0.001
Abbreviations: YKL-40 chitinase-3-like protein 1, NGAL neutrophil gelatinase-associated lipocalin, POSTN Periostin, TSLP Thymic stromal lymphopoietin, BMI body mass index, SGRQ St George’s Respiratory Questionnaire, FVC forced vital capacity, FEV1 forced expiratory volume in 1 s, % pred % predicted, ΔFEV1 Change in FEV1, SGRQ St George’s Respiratory Questionnaire, %LAA-950 The percentage of the low attenuation area below − 950 HU

ISSN: 1465-993X