Table 2 Receiver-operating characteristic (ROC) analysis for plasma biomarkers
From: Plasma YKL-40 and NGAL are useful in distinguishing ACO from asthma and COPD
| Â | ACO vs asthma | ACO vs COPD | ACO vs control | COPD vs asthma | COPD vs control | asthma vs control |
|---|---|---|---|---|---|---|
YKL-40 | ||||||
AUC (95% CI) | 0.5712[0.4932–0.6492] | 0.7138[0.6496–0.7781] | 0.8225[0.7523–0.8926] | 0.7948[0.7369–0.8527] | 0.8901[0.8428–0.9373] | 0.8360[0.7639–0.9082] |
Optimal threshold ng/ml | > 13.14 | < 12.61 | > 8.368 | > 12.90 | > 11.3 | > 8.33 |
Sensitivity/specificity | 31.37%/95.16% | 73.47%/67.65% | 80.39%/78% | 71.43%/93.55% | 80.27%/94.00% | 88.71%/78% |
NGAL | ||||||
AUC (95% CI) | 0.7517 [0.6826–0.8207] | 0.5936[0.5237–0.6636] | 0.6859[0.5943–0.7775] | 0.8000[0.7469–0.8530] | 0.7537[0.6781–0.8294] | 0.5063[0.3948–0.6178] |
Optimal threshold ng/ml | < 104.7 | > 179.1 | < 87.23 | > 104.3 | > 89.90 | > 75.43 |
Sensitivity/specificity | 92.74%/58.82% | 31.29%/93.14% | 58.00%/76.47% | 60.54%/92.74% | 60.00%/79.59% | 50.00%%/70.16 |
POSTN | ||||||
AUC (95% CI) | 0.5471[0.4713–0.6229] | 0.5224[0.4502–0.5945] | 0.5062[0.4089–0.6035] | 0.5691[0.5006–0.6376] | 0.5343[0.4505–0.6181] | 0.5440[0.4495–0.6385] |
Optimal threshold ng/ml | > 89.87 | < 112.1 | > 66.29 | < 90.45 | > 66.29 | > 85.92 |
Sensitivity/specificity | 79.8%/33.3% | 60.54%/52.94% | (92.00%/17.65%) | 43.54%/79.84% | 92.00%/23.81% | 30.00%/82.26% |
TSLP | ||||||
AUC (95% CI) | 0.5474[0.4682–0.6266] | 0.5462[0.4729–0.6195] | 0.8733[0.8118–0.9348] | 0.5230[0.4534–0.5926] | 0.8824[0.8210–0.9438] | 0.9191[0.8550–0.9833] |
Optimal threshold ng/ml | > 5.044 | > 4.012 | > 3.665 | > 3.568 | > 3.522 | > 3.568 |
Sensitivity/specificity | 91.94%/26.47% | 44.90%/71.57% | 86.00%/83.33% | 19.05%/100% | 82.00%/83.67% | 84.00%/100% |