Table 2 Sputum cell counts (absolute and relative counts)
|  | Placebo (n = 10) | SB010 (n = 9) | ||||
|---|---|---|---|---|---|---|
Screening | d29 | p-value | Screening | d29 | p-value | |
Absolute cell counts [×  103/ml] | ||||||
 Total cell count | 2854 ± 3259 2154 (935–3104) | 3334 ± 2156 2691 (1712–4233) | 0.27 | 6207 ± 7229 3509 (1782–7288) | 6845 ± 5432 5628 (3684–6279) | 1.00 |
 Alevolar Macrophages | 508 ± 555 312 (165–473) | 509 ± 369 387 (263–721) | 0.42 | 775 ± 711 539 (188–1040) | 862 ± 808 611 (460–831) | 0.65 |
 Eosinophils | 202 ± 225 88 (30–279) | 174 ± 212 88 (22–206) | 0.54 | 704 ± 1011 347 (107–544) | 196 ± 134 192 (121–234) | 0.06 |
 Neutrophils | 2083 ± 3160 1004 (464–2496) | 2596 ± 1907 2048 (1166–3345) | 0.08 | 4556 ± 6876 1828 (1429–4491) | 5642 ± 5590 3366 (2828–5398) | 0.65 |
 Lymphocytes | 20.3 ± 20.5 14 (8–29) | 13.5 ± 17.6 9 (0–22) | 0.84 | 29.6 ± 37.5 20 (8–29) | 35 ± 45.7 16 (3–36) | 0.73 |
 Monocytes | 4.6 ± 6.8 1 (0–10) | 5.2 ± 4.5 4.5 (2–9) | 0.73 | 6.8 ± 9.1 2 (0–9) | 19.3 ± 37.9 0 (0–11) | 0.80 |
Relative cell counts [% non-squamous cell] | ||||||
 Alevolar Macrophages | 23.8 ± 20.1 17.7 (8.4–41.7) | 16.7 ± 9.4 14.2 (9.6–25.4) | 0.49 | 19.8 ± 16.4 15.4 (11.2–21.9) | 17.7 ± 14.6 14.8 (7.3–24.2) | 0.57 |
 Eosinophils | 7.2 ± 4.9 5 (3.6–10.1) | 6.4 ± 9.2 2 (1–7.1) | 0.38 | 10.7 ± 12.3 6.5 (6–8) | 4.4 ± 5.4 2.7 (1.4–4) | 0.004 |
 Neutrophils | 65.2 ± 23.2 70.2 (49.6–82) | 74.5 ± 18.1 82.1 (68.1–85.8) | 0.13 | 65.2 ± 26.3 73.7 (66.6–80.2) | 74.8 ± 17.9 80.6 (70.7–86) | 0.10# |
 Lymphocytes | 0.88 ± 0.78 0.75 (0.3–1.6) | 0.4 ± 0.36 0.4 (0–0.5) | 0.17 | 0.68 ± 0.58 0.6 (0.1–1) | 0.62 ± 0.68 0.6 (0.1–0.8) | 1.0 |
 Monocytes | 0.23 ± 0.33 0.05 (0–0.3) | 0.14 ± 0.15 0.1 (0.1–0.1) | 0.87 | 0.22 ± 0.39 0.1 (0–0.1) | 0.38 ± 0.78 0 (0–0.4) | 0.90 |