Skip to main content

Advertisement

Springer Nature is making SARS-CoV-2 and COVID-19 research free. View research | View latest news | Sign up for updates

Table 2 Sputum cell counts (absolute and relative counts)

From: A GATA3-specific DNAzyme attenuates sputum eosinophilia in eosinophilic COPD patients: a feasibility randomized clinical trial

  Placebo (n = 10) SB010 (n = 9)
Screening d29 p-value Screening d29 p-value
Absolute cell counts
[×  103/ml]
 Total cell count 2854 ± 3259
2154 (935–3104)
3334 ± 2156
2691 (1712–4233)
0.27 6207 ± 7229
3509 (1782–7288)
6845 ± 5432
5628 (3684–6279)
1.00
 Alevolar Macrophages 508 ± 555
312 (165–473)
509 ± 369
387 (263–721)
0.42 775 ± 711
539 (188–1040)
862 ± 808
611 (460–831)
0.65
 Eosinophils 202 ± 225
88 (30–279)
174 ± 212
88 (22–206)
0.54 704 ± 1011
347 (107–544)
196 ± 134
192 (121–234)
0.06
 Neutrophils 2083 ± 3160
1004 (464–2496)
2596 ± 1907
2048 (1166–3345)
0.08 4556 ± 6876
1828 (1429–4491)
5642 ± 5590
3366 (2828–5398)
0.65
 Lymphocytes 20.3 ± 20.5
14 (8–29)
13.5 ± 17.6
9 (0–22)
0.84 29.6 ± 37.5
20 (8–29)
35 ± 45.7
16 (3–36)
0.73
 Monocytes 4.6 ± 6.8
1 (0–10)
5.2 ± 4.5
4.5 (2–9)
0.73 6.8 ± 9.1
2 (0–9)
19.3 ± 37.9
0 (0–11)
0.80
Relative cell counts
[% non-squamous cell]
 Alevolar Macrophages 23.8 ± 20.1
17.7 (8.4–41.7)
16.7 ± 9.4
14.2 (9.6–25.4)
0.49 19.8 ± 16.4
15.4 (11.2–21.9)
17.7 ± 14.6
14.8 (7.3–24.2)
0.57
 Eosinophils 7.2 ± 4.9
5 (3.6–10.1)
6.4 ± 9.2
2 (1–7.1)
0.38 10.7 ± 12.3
6.5 (6–8)
4.4 ± 5.4
2.7 (1.4–4)
0.004
 Neutrophils 65.2 ± 23.2
70.2 (49.6–82)
74.5 ± 18.1
82.1 (68.1–85.8)
0.13 65.2 ± 26.3
73.7 (66.6–80.2)
74.8 ± 17.9
80.6 (70.7–86)
0.10#
 Lymphocytes 0.88 ± 0.78
0.75 (0.3–1.6)
0.4 ± 0.36
0.4 (0–0.5)
0.17 0.68 ± 0.58
0.6 (0.1–1)
0.62 ± 0.68
0.6 (0.1–0.8)
1.0
 Monocytes 0.23 ± 0.33
0.05 (0–0.3)
0.14 ± 0.15
0.1 (0.1–0.1)
0.87 0.22 ± 0.39
0.1 (0–0.1)
0.38 ± 0.78
0 (0–0.4)
0.90
  1. Displayed are the mean ± SD, the median (25% - 75%) in the second row; P values were calculated by the two-sided Wilcoxon signed rank test. All values are given for the per protocol population. As tests for normality were based on small sample sizes, paired t tests were also performed for each variable yielding the same results with regard to statistical significance except for neutrophils (%) in the SB010 group. # p < 0.05 tested with paired t test