Table 5 Selected results of pathway enrichment analysis based on predicted differential gene expression
From: Integrative genomics identifies new genes associated with severe COPD and emphysema
Phenotype | Tissue | Functional category | P value for enrichment* | Overlapping genes |
|---|---|---|---|---|
Severe COPD | Lung | collagen binding involved in cell-matrix adhesion | 2.70E-03 | ITGA10, ITGA2, ITGA1 |
Severe COPD | Lung | proteasome core complex | 2.80E-02 | PSMF1, PSMB4, PSMB9 |
Severe COPD | Lung | translation factor activity, RNA binding | 3.70E-02 | TCEB3, EEFSEC, TUFM, EIF3C, EIF3CL |
%LAA-950 | Whole Blood | MHC class II protein complex | 5.20E-05 | HLA-DQB1, HLA-DRB1, HLA-DQA1, HLA-DQB2, HLA-DQA2 |
%LAA-950 | Whole Blood | PD-1 signaling | 6.30E-04 | HLA-DQB1, HLA-DRB1, HLA-DQA1, HLA-DQB2, HLA-DQA2 |
%LAA-950 | Whole Blood | Downstream TCR signaling | 8.00E-04 | PSMA4, NFKBIA, BCL10, HLA-DQB1, HLA-DRB1, HLA-DQA1, HLA-DQB2, HLA-DQA2 |
%LAA-950 | Whole Blood | Asthma | 4.80E-03 | MS4A2, HLA-DQB1, HLA-DRB1, HLA-DQA1, HLA-DQA2 |
%LAA-950 | Whole Blood | T cell receptor signaling pathway | 6.60E-03 | PSMA4, NFKBIA, BCL10, HLA-DRB1, HLA-DQA1, PVRIG, HLA-DQB2, HLA-DQA2 |
Perc15 | Lung | negative regulation of ERBB signaling pathway | 4.50E-02 | NRG1, ITGA1, UBA52 |