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Table 5 Selected results of pathway enrichment analysis based on predicted differential gene expression

From: Integrative genomics identifies new genes associated with severe COPD and emphysema

Phenotype Tissue Functional category P value for enrichment* Overlapping genes
Severe COPD Lung collagen binding involved in cell-matrix adhesion 2.70E-03 ITGA10, ITGA2, ITGA1
Severe COPD Lung proteasome core complex 2.80E-02 PSMF1, PSMB4, PSMB9
Severe COPD Lung translation factor activity, RNA binding 3.70E-02 TCEB3, EEFSEC, TUFM, EIF3C, EIF3CL
%LAA-950 Whole Blood MHC class II protein complex 5.20E-05 HLA-DQB1, HLA-DRB1, HLA-DQA1, HLA-DQB2, HLA-DQA2
%LAA-950 Whole Blood PD-1 signaling 6.30E-04 HLA-DQB1, HLA-DRB1, HLA-DQA1, HLA-DQB2, HLA-DQA2
%LAA-950 Whole Blood Downstream TCR signaling 8.00E-04 PSMA4, NFKBIA, BCL10, HLA-DQB1, HLA-DRB1, HLA-DQA1, HLA-DQB2, HLA-DQA2
%LAA-950 Whole Blood Asthma 4.80E-03 MS4A2, HLA-DQB1, HLA-DRB1, HLA-DQA1, HLA-DQA2
%LAA-950 Whole Blood T cell receptor signaling pathway 6.60E-03 PSMA4, NFKBIA, BCL10, HLA-DRB1, HLA-DQA1, PVRIG, HLA-DQB2, HLA-DQA2
Perc15 Lung negative regulation of ERBB signaling pathway 4.50E-02 NRG1, ITGA1, UBA52
  1. *P values were corrected for multiple testing using g:SCS method (see Additional file 1: Supplementary Methods)