Integrative genomics identifies new genes associated with severe COPD and emphysema

Respiratory Research

Table 4 Colocalized variants in validated genes and association statistics in corresponding GWAS and eQTL datasets

Locus	Phenotype	Gene	Tissue	Top colocalized variant	Variant CLPP	GWAS P value	eQTL P value
6q22	%LAA-950	DCBLD1	Lung	rs34882116	0.13	2.87E-05	1.28E-11
15q25	Severe COPD	PSMA4	Blood	rs56077333	0.21	1.57E-18	4.16E-06
15q25	%LAA-950	PSMA4	Blood	rs56077333	0.14	2.64E-09	4.16E-06
17q21	Severe COPD	WNT3	Lung	rs199520	0.21	1.75E-06	1.30E-12
19q13	Severe COPD	EGLN2	Blood	rs35755165	0.12	9.91E-09	1.87E-06
19q13	%LAA-950	LILRA3	Blood	rs380267	0.28	3.32E-05	4.54E-47

CLPP = Colocalization posterior probability, the probability that a particular variant is causal in both GWAS and eQTL. A CLPP of 0.01 or greater previously demonstrated high accuracy and precision (see Additional file 1: Supplementary Methods), [15]. Only top colocalized variants, a variant with highest CLPP for each gene/tissue, are shown

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