Table 3 Result of association analysis between imputed gene expression and severe COPD and emphysema (%LAA-950 and Perc15) with validation
From: Integrative genomics identifies new genes associated with severe COPD and emphysema
Genetic Loci | Phenotype | Gene | Tissue | Discovery Z score | Discovery P value | Validation Z score | Validation P value |
|---|---|---|---|---|---|---|---|
4q22 | Severe COPD | FAM13A | Blood | −5.46 | 4.80E-08 | NA | NA |
4q22 | Severe COPD | GPRIN3 | Lung | 4.95 | 7.40E-07 | 0.94 | 3.40E-01 |
5q11 | Perc15 | ITGA1 | Lung | −4.89 | 1.00E-06 | NA | NA |
6p21 | %LAA-950 | ATF6B | Lung | −4.48 | 7.30E-06 | −1.33 | 1.80E-01 |
6q22 | %LAA-950 | DCBLD1 | Lung | 4.53 | 5.80E-06 | 3.81 | 1.40E-04 |
15q25 | Severe COPD | HYKK | Blood | −8.33 | 8.20E-17 | NA | NA |
15q25 | Severe COPD | PSMA4 | Blood | 7.62 | 2.50E-14 | 7.57 | 3.80E-14 |
15q25 | %LAA-950 | HYKK | Blood | −5.64 | 1.70E-08 | NA | NA |
15q25 | %LAA-950 | PSMA4 | Blood | 4.92 | 8.50E-07 | 5.1 | 3.40E-07 |
17q21 | Severe COPD | WNT3 | Lung | 4.85 | 1.20E-06 | 4.6 | 4.30E-06 |
19q13 | Severe COPD | EGLN2 | Blood | 4.89 | 1.00E-06 | 4.35 | 1.30E-05 |
19q13 | Severe COPD | RAB4B | Blood | −4.78 | 1.70E-06 | −3.82 | 1.30E-04 |
19q13a | %LAA-950 | LILRA3 | Blood | −4.62 | 3.80E-06 | −4.13 | 3.60E-05 |