Table 2 Demographic characteristics of individuals in the analysis of quantitative emphysema
From: Integrative genomics identifies new genes associated with severe COPD and emphysema
| Â | COPDGene-NHW | COPDGene-AA | ECLIPSE | NETT | Norway GenKOLS | ||||
|---|---|---|---|---|---|---|---|---|---|
Cases | Noncases | Cases | Noncases | Cases | Control Subjects | Cases | Cases | Control Subjects | |
N | 3243 | 3062 | 901 | 2132 | 1393 | 145 | 332 | 417 | 406 |
Age, years (SD) | 64.4 (8.3) | 59.7 (8.6) | 58.6 (8.1) | 53 (6.0) | 63.4 (7.0) | 57.3 (9.4) | 67.4 (5.9) | 64.2 (9.3) | 55.6 (9.4) |
Smoking pack-years (SD) | 54.4 (27.5) | 39.7 (21.5) | 42 (23.1) | 36.6 (20.5) | 49.8 (26.7) | 31.8 (26.6) | 65.8 (30.8) | 31 (18.2) | 19.8 (14.1) |
Men, n (%) | 1832 (56.5) | 1462 (47.7) | 497 (55.2) | 1209 (56.7) | 911 (65.4) | 85 (58.6) | 212 (63.9) | 263 (63.1) | 216 (53.2) |
Current Smokers, n (%) | 1199 (37) | 1263 (41.2) | 595 (66) | 1838 (86.2) | 480 (34.5) | 58 (40.0) | 0 (0) | 210 (50.4) | 164 (40.4) |
FEV1, % predicted (SD) | 57.4 (23.0) | 91.3 (14.8) | 59.5 (22) | 92.2 (16.5) | 47.4 (15.5) | 108.6 (13.4) | 28.2 (7.3) | 52.5 (16.9) | 94.9 (9.2) |
FEV1/FVC (SD) | 0.517 (0.136) | 0.779 (0.050) | 0.550 (0.120) | 0.800 (0.052) | 0.442 (0.115) | 0.792 (0.055) | 0.317 (0.061) | 0.523 (0.125) | 0.791 (0.042) |
LAA-950, % (range) | 7.5 (0–61.9) | 1.2 (0–26.9) | 4.6 (0–61.2) | 0.7 (0–35.8) | 16.3 (0.1–58.7) | 2.3 (0.1–14.2) | 15 (0.3–49.9) | 7 (0–53.2) | 0.5 (0–34.4) |
Perc15, HU (SD) | − 938.1 (26.8) | −909.9 (22.8) | − 926.5 (32) | − 893.4 (28.1) | −950.9 (25.9) | − 906.2 (25.9) | − 949.7 (17.8) | − 932.8 (30.2) | −891.6 (26.3) |