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Table 2 Demographic characteristics of individuals in the analysis of quantitative emphysema

From: Integrative genomics identifies new genes associated with severe COPD and emphysema

  COPDGene-NHW COPDGene-AA ECLIPSE NETT Norway GenKOLS
Cases Noncases Cases Noncases Cases Control Subjects Cases Cases Control Subjects
N 3243 3062 901 2132 1393 145 332 417 406
Age, years (SD) 64.4 (8.3) 59.7 (8.6) 58.6 (8.1) 53 (6.0) 63.4 (7.0) 57.3 (9.4) 67.4 (5.9) 64.2 (9.3) 55.6 (9.4)
Smoking pack-years (SD) 54.4 (27.5) 39.7 (21.5) 42 (23.1) 36.6 (20.5) 49.8 (26.7) 31.8 (26.6) 65.8 (30.8) 31 (18.2) 19.8 (14.1)
Men, n (%) 1832 (56.5) 1462 (47.7) 497 (55.2) 1209 (56.7) 911 (65.4) 85 (58.6) 212 (63.9) 263 (63.1) 216 (53.2)
Current Smokers, n (%) 1199 (37) 1263 (41.2) 595 (66) 1838 (86.2) 480 (34.5) 58 (40.0) 0 (0) 210 (50.4) 164 (40.4)
FEV1, % predicted (SD) 57.4 (23.0) 91.3 (14.8) 59.5 (22) 92.2 (16.5) 47.4 (15.5) 108.6 (13.4) 28.2 (7.3) 52.5 (16.9) 94.9 (9.2)
FEV1/FVC (SD) 0.517 (0.136) 0.779 (0.050) 0.550 (0.120) 0.800 (0.052) 0.442 (0.115) 0.792 (0.055) 0.317 (0.061) 0.523 (0.125) 0.791 (0.042)
LAA-950, % (range) 7.5 (0–61.9) 1.2 (0–26.9) 4.6 (0–61.2) 0.7 (0–35.8) 16.3 (0.1–58.7) 2.3 (0.1–14.2) 15 (0.3–49.9) 7 (0–53.2) 0.5 (0–34.4)
Perc15, HU (SD) − 938.1 (26.8) −909.9 (22.8) − 926.5 (32) − 893.4 (28.1) −950.9 (25.9) − 906.2 (25.9) − 949.7 (17.8) − 932.8 (30.2) −891.6 (26.3)
  1. Cases are GOLD grade 1 or more severe (as in NETT) cases; control subjects are smokers who have normal spirometry (GOLD grade 0); noncases include GOLD grade 0 and PRISm (preserved ratio, impaired spirometry) subjects
  2. Definition of abbreviations: LAA-950 low attenuation area using a threshold of − 950 HU, COPD chronic obstructive pulmonary disease, COPDGene Genetic Epidemiology of COPD, ECLIPSE Evaluation of COPD Longitudinally to Identify Predictive Surrogate Endpoints, GenKOLS Genetics of COPD, Norway, GOLD Global Initiative for Chronic Obstructive Lung Disease, HU Hounsfield units, NETT National Emphysema Treatment Trial, Perc15 HU at the 15th percentile of the density histogram