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Table 1 Demographic characteristics of individuals in the analysis of severe COPD

From: Integrative genomics identifies new genes associated with severe COPD and emphysema

  COPDGene-NHW COPDGene-AA ECLIPSE NETT/NAS Norway GenKOLS
Cases Control Subjects Cases Control Subjects Cases Control Subjects Cases Control Subjects Cases Control Subjects
N 1390 2534 352 1749 999 178 373 435 383 808
Age, years (SD) 65.2 (7.8) 59.5 (8.7) 60.6 (8.1) 52.8 (6.0) 63.5 (7.0) 57.5 (9.4) 67.5 (5.8) 69.8 (7.5) 66.7 (9.7) 55.6 (9.7)
Smoking pack-years (SD) 58.7 (28.4) 37.8 (20.3) 43.9 (23.4) 36.4 (20.1) 50.7 (26.3) 32.1 (24.8) 66.4 (30.7) 40.7 (27.9) 33.0 (19.9) 19.7 (13.6)
FEV1, % predicted (SD) 34.0 (9.9) 96.8 (11.0) 34.8 (10.4) 98.4 (12.2) 36.5 (8.6) 107.8 (13.6) 28.1 (7.4) 100.0 (13.2) 34.4 (10.3) 94.9 (9.2)
FEV1/FVC (SD) 0.390 (0.103) 0.779 (0.050) 0.430 (0.105) 0.800 (0.052) 0.387 (0.095) 0.790 (0.053) 0.324 (0.064) 0.793 (0.0527) 0.412 (0.108) 0.791 (0.043)
Men, n (%) 803 (58) 1250 (49) 204 (58) 1017 (58) 698 (70) 103 (58) 238 (64.0) 435 (100) 235 (61) 405 (50)
  1. Definition of abbreviations: COPD chronic obstructive pulmonary disease, COPDGene Genetic Epidemiology of COPD, ECLIPSE Evaluation of COPD Longitudinally to Identify Predictive Surrogate Endpoints, GenKOLS Genetics of COPD, Norway, NETT National Emphysema Treatment Trial, NAS Normative Aging Study