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Table 2 Characteristics of the cohorts and cases for each of the 11 study outcomes

From: Adverse events profile of oral corticosteroids among asthma patients in the UK: cohort study with a nested case-control analysis

 

Bone-related conditions

Hypertension

Peptic ulcer

Severe infections

Herpes zoster

DM2

Cataract

Glaucoma

CKD

Affective disorders

Cardiovascular events

Cohort analysis

 Individuals at cohort entry, n

219,174

223,940

267,569

244,207

262,847

262,304

265,964

269,368

267,138

165,900

260,995

 Individuals with cohort entry on 1 January 2000, n

40,484

37,250

46,439

44,621

46,016

46,046

46,324

46,892

47,549

30,722

44,549

 Individuals with cohort entry after 1 January 2000, n

178,690

186,690

221,130

199,586

216,831

216,258

219,640

222,476

219,589

135,178

216,446

 Cases, n

8927

8162

836

16,192

4175

5195

5356

1473

8825

4965

4028

 Total follow-up time, py

682,398

653,565

850,874

744,410

824,689

820,055

830,289

854,208

825,108

525,577

816,959

Nested case-control analysis

 Casesa, n

8907

8148

835

16 160b

2748c

4163

5189

5327

1467

8778

4962

4014

 Controls, n

35,445

32,431

3328

64,316b

10839c

16,605

20,715

21,019

5832

34,762

19,809

15,945

 Mean age of cases, years (SD)

54.3 (+/− 19.6)

58.9 (+/− 12.9)

63.1 (+/−  16.7)

51.8 (+/−  19.7)b

58.6 (+/−  20.8)c

57.3 (+/−  17.5)

58.1 (+/−  15.3)

72.7 (+/−  10.9)

68.0 (+/−  13.0)

71.3 (+/−  12.0)

40.8 (+/−  16.7)

67.4 (+/−  12.4)

 Females among cases, %

69.1

57.4

60.2

67.7b

64.6c

66.0

60.1

68.9

62.9

73.1

62.2

53.0

  1. Abbreviations: CKD chronic kidney disease, DM2 diabetes mellitus type 2, py person-years, SD standard deviation
  2. aCases from the cohort analysis that could be matched to at least 1 control on the index date, duration of follow-up (+/− 2 years), year of birth (+/− 2 years), sex, and duration of history on the database (+/− 0 years)
  3. bMain analysis
  4. cSensitivity analysis restricted to patients with integrated hospital episode statistics linkage