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Table 2 Characteristics of the cohorts and cases for each of the 11 study outcomes

From: Adverse events profile of oral corticosteroids among asthma patients in the UK: cohort study with a nested case-control analysis

  Bone-related conditions Hypertension Peptic ulcer Severe infections Herpes zoster DM2 Cataract Glaucoma CKD Affective disorders Cardiovascular events
Cohort analysis
 Individuals at cohort entry, n 219,174 223,940 267,569 244,207 262,847 262,304 265,964 269,368 267,138 165,900 260,995
 Individuals with cohort entry on 1 January 2000, n 40,484 37,250 46,439 44,621 46,016 46,046 46,324 46,892 47,549 30,722 44,549
 Individuals with cohort entry after 1 January 2000, n 178,690 186,690 221,130 199,586 216,831 216,258 219,640 222,476 219,589 135,178 216,446
 Cases, n 8927 8162 836 16,192 4175 5195 5356 1473 8825 4965 4028
 Total follow-up time, py 682,398 653,565 850,874 744,410 824,689 820,055 830,289 854,208 825,108 525,577 816,959
Nested case-control analysis
 Casesa, n 8907 8148 835 16 160b
2748c
4163 5189 5327 1467 8778 4962 4014
 Controls, n 35,445 32,431 3328 64,316b
10839c
16,605 20,715 21,019 5832 34,762 19,809 15,945
 Mean age of cases, years (SD) 54.3 (+/− 19.6) 58.9 (+/− 12.9) 63.1 (+/−  16.7) 51.8 (+/−  19.7)b
58.6 (+/−  20.8)c
57.3 (+/−  17.5) 58.1 (+/−  15.3) 72.7 (+/−  10.9) 68.0 (+/−  13.0) 71.3 (+/−  12.0) 40.8 (+/−  16.7) 67.4 (+/−  12.4)
 Females among cases, % 69.1 57.4 60.2 67.7b
64.6c
66.0 60.1 68.9 62.9 73.1 62.2 53.0
  1. Abbreviations: CKD chronic kidney disease, DM2 diabetes mellitus type 2, py person-years, SD standard deviation
  2. aCases from the cohort analysis that could be matched to at least 1 control on the index date, duration of follow-up (+/− 2 years), year of birth (+/− 2 years), sex, and duration of history on the database (+/− 0 years)
  3. bMain analysis
  4. cSensitivity analysis restricted to patients with integrated hospital episode statistics linkage