Fig. 4
From: Impaired diversity of the lung microbiome predicts progression of idiopathic pulmonary fibrosis
Bleomycin-treated fibrosis alters microbiome in mice lung. C57BL/6 J mice were treated with bleomycin (Bleo) and normal saline (NS) solution as described in methods. a Total number of tuf gene in BALF was measured by real-time PCR. b The alpha diversity was shown by a box plot. Box plots are expressed as the median ± IQRs. Mann–Whitney U test. *: p < 0.05. c Phylum level of operational taxonomic units from 16S rRNA gene sequences. Microbial subjects with > 1.0% relative abundance per sample are shown. d Two-dimensional PCoA plot of microbial communities in lung from bleomycin- and saline-treated mice, indicated as significant by PERMANOVA (p = 0.0209). Axes show percentage of contribution, PC1: 50.1%, PC2: 23.7%