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Fig. 5 | Respiratory Research

Fig. 5

From: Role of ATP-sensitive potassium channels on hypoxic pulmonary vasoconstriction in endotoxemia

Fig. 5

Pressure-flow data obtained in isolated, perfused mouse lungs of untreated and LPS treated mice (a) (n = 8 for controls (□) and n = 7 for LPS (■), trend lines). Lungs were isolated and perfused with a flow of 25, 50, 75, and 100 ml* kg − 1 * min − 1 during ventilation with a normoxic (straight line) or hypoxic gas mixture (dashed line), respectively, and the resulting perfusion pressure (PAP) was recorded. b: Pressure-flow relationships were obtained under perfusion with 1 μM PNU 37883A (n = 7 for PNU () and n = 7 for LPS/PNU (), straight line normoxic gas, dashed line hypoxic gas. c: Pzf increases upon hypoxic ventilation as well as RLIN (d). Perfusion with 1 μM PNU-37883A increased Pzf as well as RLIN during hypoxic ventilation (Fig. 5c and d). (nx: normoxia, hx: hypoxia, *P < 0.05 vs. corresponding control, # vs. LPS, § vs corresponding normoxia; mean ± SEM, tested with ANOVA, for homogeneity and post hoc Tukey)

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