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Table 3 Multiple regression analysis predicting FEV1%, TLCO%, RV/TLC, 6MWD, desaturation on exertion, CRP, fibrinogen and sputum neutrophils

From: Relationship of CT-quantified emphysema, small airways disease and bronchial wall dimensions with physiological, inflammatory and infective measures in COPD

 

B coefficient

Standardised B coefficient

significance

FEV1%

 %LAA<− 950

− 0.42

− 0.34

< 0.001

 E/I MLD

− 180.8

− 0.56

< 0.001

 BMI

−0.56

− 0.20

0.010

TLCO%

 %LAA<− 950

−0.62

−0.37

< 0.001

 FEV1%

0.49

−0.39

< 0.001

 Gender

−7.5

−0.19

0.014

RV/TLC

 E/I MLD

0.75

0.30

0.003

 FEV1%

−0.003

−0.32

0.002

 Gender

0.07

0.28

< 0.001

6MWD (metres)

 FEV1%

3.03

0.41

< 0.001

 BMI

−5.19

−0.26

0.003

 Gender

−38.2

−0.17

0.044

Desaturation on exertion (%)

 %LAA<−950

0.041

0.73

< 0.001

 BMI

0.032

0.248

0.004

 Gender

0.233

0.164

0.037

CRP (mg/L)

 %LAA<− 950

−0.026

−0.34

< 0.001

Fibrinogen (g/L)

 %LAA<−950

−0.020

−0.28

0.003

 Age

0.022

0.216

0.020

Sputum Neutrophils (%)

 Current smoker

−21.1

−0.29

0.018

  1. %LAA<−950, E/I MLD, PI10, bronchiectasis, FEV1% and demographics variables (age, gender, current smoking status, pack years and BMI) were combined into a regression model to predict each of the dependent variables. Only variables that made a significant difference to the model are included in the results. The natural log of CRP and desaturation on exertion (+ 1) were used for this analysis to normalise the distribution of the residuals
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Respiratory Research

ISSN: 1465-993X

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