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Table 2 Spearman’s correlation analysis between CT parameters, pulmonary function tests, functional markers, blood and sputum markers

From: Relationship of CT-quantified emphysema, small airways disease and bronchial wall dimensions with physiological, inflammatory and infective measures in COPD

  %LAA<− 950 E/I MLD Pi10
Pulmonary Function Tests
 FEV1% −0.49*** −0.63*** − 0.11
 FVC% 0.06 −0.21* − 0.31**
 FEV1/FVC −0.72*** − 0.64*** 0.12
 TLCO% −0.51*** −0.34*** 0.01
 RV% 0.36*** 0.64*** −0.05
 RV/TLC 0.19* 0.62*** 0.16
Functional Markers
 6MWD (meters) −0.14 −0.10 − 0.11
 Desaturation on exertion (%) 0.56*** 0.27** −0.11
Blood Markers
 Blood neutrophils (109L) −0.06 −0.11 0.15
 Blood eosinophils (109L) 0.15 0.01 0.01
 Fibrinogen (g/L) −0.20* − 0.04 0.21*
 CRP (mg/L) −0.27** −0.28** 0.25*
 Procalcitonin (μg/L) −0.01 −0.06 0.18*
Sputum Differential
 %neutrophils 0.17 0.19 −0.10
 %eosinophils 0.16 0.04 −0.11
  1. Spearman’s r values given. N = 122 apart from associations with gas transfer (n = 117), plethysmography (n = 113), 6MWT parameters (n = 120), blood white cells and procalcitonin (n = 121), fibrinogen (n = 109) and sputum white cell differential (n = 66). *p < 0.05, **p < 0.01, ***p < 0.001