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Table 1 Characteristics of study subjects included in the study

From: Relationship of CT-quantified emphysema, small airways disease and bronchial wall dimensions with physiological, inflammatory and infective measures in COPD

 

N = 122

GOLD 2 (N = 56)

GOLD 3 (N = 49)

GOLD 4 (N = 17)

P value

Age (years)

67.0 (11.0)

67.5 (13)

67.0 (10)

65.0 (10)

0.992

Male

67

31

25

11

0.618

BMI (kg/m2)

27.1 (6.9)

27.7 (7.3)

26.5 (8.0)

25.4 (7.2)

0.054

Current smoker

46

21

18

7

0.947

Pulmonary Function

 FEV1%

47.2 (23.7)

59.1 (12.9) #^

38.8 (10.5)*^

26.2 (5.9)*#

< 0.001

 FEV1/FVC

0.43 (0.12)

0.50 (0.10) #^

0.38 (0.15) *^

0.29 (0.08) *#

< 0.001

 FEF75–25%

13.2 (8.3)

17.2 (6.4) #^

11.0 (4.7) *^

6.8 (2.2) *#

< 0.001

 TLCO%

58.3 (28.7)

70.4 (23.9) #^

53.0 (22.8)*

44.6 (11.8)*

< 0.001

 RV%

144.8 (59.2)

133.8 (38.9) #^

159.2 (48.1)*

202.7 (96.6)*

< 0.001

 RV/TLC

0.54 (0.14)

0.49 (0.14) #^

0.58 (0.10)*

0.64 (0.16)*

< 0.001

Functional Markers

 6MWD (meters)

303.5 (174)

360.0 (155)^

300.0 (156)^

169.5 (129)*#

< 0.001

 Desaturation on Exertion (%)

4.0 (5.0)

3.0 (3.0) #^

5.0 (8.0)*

6.0 (6.5)*

0.001

Blood Measures

 Blood neutrophils (109L)

4.8 (1.6)

4.8 (1.6)

4.7 (2.0)

4.8 (1.6)

0.914

 Blood eosinophils (109L)

0.20 (0.20)

0.20 (0.20)

0.20 (0.20)

0.20 (0.20)

0.082

 Fibrinogen (g/L)

4.8 (1.1)

4.8 (1.1)

4.8 (1.0)

5.0 (1.4)

0.813

 CRP (mg/L)

5.0 (7.0)

5.0 (6.8)

4.0 (6.5)

6.0 (7.0)

0.570

 Procalcitonin (μg/L)

0.059 (0.03)

0.056 (0.02)

0.061 (0.03)

0.073 (0.05)

0.236

Sputum Differential

 Sputum Neutrophils(%)

45.9 (70.8)

17.7 (62.6)

44.3 (75.8)

71.2 (39.3)

0.110

 Sputum Eosinophils (%)

2.02 (5.2)

1.97 (4.0)

2.20 (5.7)

2.62 (4.8)

0.596

CT Measures

 Emphysema (%LAA<− 950)

12.0 (20.7)

9.6 (13.1)#^

15.8 (26.9)*

24.8 (12.3)*

< 0.001

 Bronchial wall area (Pi10)

3.80 (0.12)

3.79 (0.13)

3.78 (0.10)^

3.84 (0.05)#

0.040

 Small airways disease (E/I MLD)

0.92 (0.07)

0.88 (0.07) #^

0.93 (0.05)*

0.96 (0.03)*

< 0.001

 Bronchiectasis

8 (6.6)

1 (1.8)

5 (10.2)

2 (11.8)

0.143

  1. Values given as medians (IQR). Males, smoking status and bronchiectasis given as number of subjects. N = 122 for whole cohort. For gas transfer n = 117, plethysmography n = 113, 6MWT parameters n = 120, blood white cells and procalcitonin n = 121, fibrinogen n = 109, sputum white cell differential n = 66. P value indicates difference between GOLD groups where < 0.05 taken as significant. * significant difference vs. GOLD 2 group, # significant difference vs. GOLD 3 group and ^ significant difference vs. GOLD 4 group
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Respiratory Research

ISSN: 1465-993X

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