Table 3 Unadjusted and adjusted hazard ratios for COPD exacerbations according to IgG subclass levels in the MACRO and STATCOPE cohorts

IgG^a

Hazard Ratio (95% CI)

P

Hazard Ratio (95% CI)

P

IgG1

1.43 (1.23–1.67)

< 0.001

1.30 (1.10–1.54)

0.002

IgG2

1.29 (1.15–1.45)

< 0.001

1.19 (1.05–1.35)

0.006

IgG3

0.99 (0.88–1.11)

0.84

0.95 (0.85–1.07)

0.39

IgG4

1.09 (1.02–1.17)

0.009

1.05 (0.98–1.13)

0.17

IgG^a

Hazard Ratio (95% CI)

P

Hazard Ratio (95% CI)

P

IgG1

1.45 (1.20–1.75)

< 0.001

1.25 (1.02–1.54)

0.035

IgG2

1.32 (1.15–1.52)

< 0.001

1.17 (1.01–1.36)

0.046

IgG3

1.10 (0.98–1.25)

0.11

0.99 (0.87–1.13)

0.90

IgG4

1.01 (0.94–1.08)

0.76

0.96 (0.89–1.04)

0.33