Fig. 5
From: The topical study of inhaled drug (salbutamol) delivery in idiopathic pulmonary fibrosis
Plasma salbutamol concentrations. (a) Dose normalised plasma salbutamol concentration per treatment group. Treatment group 1.5 μm salbutamol 50 μg delivered by the STAG device (■), 6 μm salbutamol 50 μg delivered by the STAG device (●), nebulised 2.5 mg salbutamol (▲), 400 μg salbutamol delivered by the pMDI plus spacer (◊). (b) Plasma salbutamol concentration delivered by pMDI plus spacer. Individual subject PK profiles (○) and observed geometric mean PK profile (blue line) for the IPF subjects. Predicted PK profile from asthmatics (red line) [21], predicted PK for healthy subjects (green line) [20]