Fig. 3

EC proliferation and vascular barrier integrity were impaired in Cdc42-KO mice compared to control mice. a Representative micrographs showing EC proliferation. The double-positive cells exhibiting simultaneous green and red fluorescence were proliferating ECs, n = 5 mice per group. Scale bar, 50 μm. b Graphic presentation of significant differences in cell proliferation, n = 5 mice per group. *P < 0.05 (Student’s t test). c Pulmonary transvascular Evans Blue flux, a finding indicative of defective barrier recovery, in KO mice at baseline and on day 7 during the repair phase, n = 4 mice per group. *P < 0.05 (Student’s t test). d The wet-to-dry weight ratio was increased in Cdc42-KO mice compared to control mice at baseline and on day 7 after LPS challenge, n = 4 mice per group. *P < 0.05 (Student’s t test)