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Fig. 2 | Respiratory Research

Fig. 2

From: IL-1β mediates lung neutrophilia and IL-33 expression in a mouse model of viral-induced asthma exacerbation

Fig. 2

BALF and lung tissue inflammation were reduced in IL-1β−/− mice at exacerbation. Total protein (a) and total cells (b) were analysed from BALF. Differential cell count in BALF was quantified from cytospinned and May-Grünwald/Giemsa-stained cells (c). mRNA expression of Muc5ac was quantified in lung tissue homogenates using RT-qPCR (d). The relative gene expression was related to the reference gene 18S and normalised to the fold change of HDM/Saline control. Data are presented as mean ± SEM, n = 4–13 mice in each group. ## = p < 0.01 compared to respective HDM/Saline control and # = p < 0.05 compared to respective HDM/Saline control. The comparison between WT and IL-1β−/− at exacerbation is indicated by * = p < 0.05. Representative H&E stained lung tissue sections from both WT and IL-1β−/− (e). Scale bar indicates 100 μm for all four micrograph images

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