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Table 2 Cell-Type Distinguishing Genes Most Highly Elevated by RT

From: Radiation-induced pulmonary gene expression changes are attenuated by the CTGF antibody Pamrevlumab

  18w Fc vs noRT 30w Fc vs noRT
Gene ID Description RT RT + FG RT RT + FG
Mast Cell
 Mcpt4 mast cell protease 4 109.9 5.9 10.7 2.2
 Cpa3 carboxypeptidase A3, mast cell 94.2 3.3 19.9 3.0
 Cma2 chymase 2, mast cell protease 9 51.6 3.6 9.0 2.0
 Cma1 chymase 1, mast cell 46.5 2.7 4.8 1.1
 Tpsg1 tryptase gamma 1, mast cell protease 2 22.7 2.7 40.2 5.0
 Mrgprb1 MAS-related GPR, member B1 20.3 2.9 8.5 1.7
 Darc Duffy blood group, chemokine receptor 18.5 1.9 2.3 0.9
 Tpsb2 tryptase beta 2, mast cell protease 6 18.0 2.5 5.5 3.8
Macrophage
 Mmp12 matrix metallopeptidase 12 24.0 0.4 6.0 1.2
 Trem2 triggering receptor expressed on myeloid cells 2 15.5 1.4 7.0 1.6
 Msr1 macrophage scavenger receptor 1 10.0 0.5 5.1 1.2
 Cd200r1 CD200 receptor 1 7.1 1.0 3.1 1.1
 Ccl3 chemokine ligand 3 6.9 0.8 1.3 0.4
 Ms4a7 membrane-spanning 4-domains, subfamily A, member 7 6.8 1.0 2.5 0.9
 Fcgr2b Fc receptor, IgG, low affinity IIb 6.6 0.7 2.2 1.3
 Ms4a6d membrane-spanning 4-domains, subfamily A, member 6D 6.5 0.4 2.4 1.2
Dendritic Cell
 Cxcl9 chemokine (C-X-C motif) ligand 9 79.8 4.0 1.1 0.5
 Kynu kynureninase 6.5 0.8 2.3 1.3
 Dnase1l3 deoxyribonuclease 1-like 3 5.6 2.5 0.9 1.0
 Serpina3g serine peptidase inhibitor, clade A, member 3G 5.3 1.1 1.6 1.1
 Ppfia4 protein tyrosine phosphatase, f polypeptide, interacting, a4 5.1 1.3 2.5 1.3
 Ffar2 free fatty acid receptor 2 4.1 1.8 1.8 0.9
 Itgax integrin alpha X 4.1 0.7 1.9 0.8
 Ccl5 chemokine (C-C motif) ligand 5 3.9 1.7 0.9 0.8
Mesenchymal Cell
 Dlk1 delta-like 1 homolog (Drosophila) 15.2 4.7 26.3 10.4
 Timp1 tissue inhibitor of metalloproteinase 1 8.2 0.4 3.6 0.8
 Fn1 fibronectin 1 7.4 1.3 3.9 1.7
 Wisp1 WNT1 inducible signaling pathway protein 1 5.3 0.9 2.4 1.5
 Ptx3 pentraxin related gene 4.7 1.1 1.6 1.2
 Col5a2 collagen, type V, alpha 2 4.5 0.6 1.7 1.1
 Wisp2 WNT1 inducible signaling pathway protein 2 4.0 0.9 2.7 1.3
 Fstl1 follistatin-like 1 4.0 1.0 2.4 1.3
Neutrophil
 Clec7a C-type lectin domain family 7, member a 6.0 0.7 1.5 0.6
 Aif1 allograft inflammatory factor 1 4.1 1.1 2.0 1.1
 Ffar2 free fatty acid receptor 2 4.1 1.8 1.8 0.9
 P2ry13 purinergic receptor P2Y, G-protein coupled 13 2.7 0.4 1.3 0.9
 Fpr1 formyl peptide receptor 1 2.4 0.7 1.6 0.8
 Lst1 leukocyte specific transcript 1 2.3 0.8 1.1 0.8
 Mnda myeloid cell nuclear differentiation antigen 2.1 1.5 1.5 1.1
B-cell
 Igl-V1 immunoglobulin lambda chain (IgL) mRNA 8.0 1.2 0.7 1.4
 March1 membrane-associated ring finger (C3HC4) 1 3.3 1.1 1.7 1.3
 Ulbp1 UL16 binding protein 1 3.3 0.7 1.8 1.3
 Cd22 CD22 antigen 3.0 2.4 1.3 1.3
 H2-DMb2 histocompatibility 2, class II, locus Mb2 2.8 1.1 0.9 1.3
 Tlr1 toll-like receptor 1 2.7 1.0 1.1 1.1
 Mef2c myocyte enhancer factor 2C 2.2 1.7 1.5 0.9
Endothelial Cell
 Col4a1 collagen, type IV, alpha 1 3.20 0.6 1.82 1.2
 Col4a2 collagen, type IV, alpha 2 3.11 0.5 1.76 1.2
 Fabp4 fatty acid binding protein 4, adipocyte 3.01 1.2 1.73 0.5
 Mgp matrix Gla protein 2.07 0.7 1.39 1.1
Multiple Potential Cell Sources
 Ankrd34b ankyrin repeat domain 34B 224.3 8.9 8.9 1.1
 Chl1 cell adhesion molecule with homology to L1CAM 93.8 1.3 15.6 1.0
 Ucma upper zone of growth plate and cartilage matrix associated 71.2 1.8 9.9 1.2
 Tnfsf18 tumor necrosis factor (ligand) superfamily, member 18 46.8 3.6 2.8 1.0
 Gdf3 growth differentiation factor 3 32.1 3.9 4.2 1.1
 Ear5 eosinophil-associated, ribonuclease A family, member 5 29.5 2.1 18.3 1.6
 Ccl8 chemokine (C-C motif) ligand 8 29.0 2.0 5.4 0.9
 Dio3 deiodinase, iodothyronine type III 25.6 1.4 10.3 1.1
  1. Fold-change (Fc) values are relative to unirradiated (noRT) controls for RT alone and RT + FG-3019 (FG) treatment begun 16 weeks after RT