Table 3 Medication collected during the year prior to index date in (A) all patients with mild to moderate and severe asthma and in (B) in patients after exclusion with a concurrent COPD diagnosis. Age adjusted data presented as number (%)
A | B | |||||
|---|---|---|---|---|---|---|
Full study population | Asthma only (no COPD) | |||||
Mild to moderate (n = 17,934) | Severe (n = 790) | P value | Mild to moderate (n = 16,142) | Severe (n = 561) | P-value | |
Asthma medications | 11,695 (65.2) | 696 (88.1) | <0.001 | 10,063 (62.3) | 487 (86.8) | <0.001 |
Short-acting β2-agonists (SABA) | 5984 (33.4) | 394 (49.9) | <0.001 | 5180 (32.1) | 280 (49.9) | <0.001 |
Inhaled corticosteroids (ICS) | 5326 (29.7) | 164 (20.8) | <0.001 | 4779 (29.6) | 123 (21.9) | <0.001 |
Long-acting β2-agonists (LABA) | 2052 (11.4) | 107 (13.5) | 0.079 | 1700 (10.5) | 79 (14.0) | 0.009 |
Short acting anticholinergics | 345 (1.9) | 25 (3.1) | 0.020 | 144 (0.9) | 12 (2.1) | 0.005 |
Long acting anticholinergics | 814 (4.5) | 104 (13.2) | <0.001 | 160 (1.0) | 14 (2.5) | 0.001 |
Fixed ICS/LABA combination | 4631 (25.8) | 511 (64.6) | <0.001 | 3723 (23.1) | 351 (62.6) | <0.001 |
Salbutamol and ipratropiuma | 169 (0.9) | 25 (3.2) | <0.001 | 62 (0.4) | 11 (2.0) | <0.001 |
Montelukastb | 1005 (5.6) | 169 (21.4) | <0.001 | 878 (5.4) | 130 (23.2) | <0.001 |
Methylxanthines | 76 (0.4) | 14 (1.7) | <0.001 | 48 (0.3) | 4 (0.8) | 0.176 |
Anti-IgE treatment (omalizumab) | 0 (0.0) | 7 (0.9) | <0.001 | 0 (0.0) | 6 (1.1) | <0.001 |
Systemic corticosteroids (OCS) | 3132 (17.5) | 295 (37.4) | <0.001 | 2581 (16.0) | 192 (34.2) | <0.001 |
N-acetylcysteine | 2226 (12.4) | 191 (24.2) | <0.001 | 1521 (9.4) | 105 (18.7) | <0.001 |
Antibiotics and oral steroidsc | 697 (3.9) | 124 (15.7) | <0.001 | |||
Cardiovascular medications | 6437 (35.9) | 336 (42.5) | <0.001 | 5126 (31.8) | 211 (37.6) | 0.004 |
Anti-dyslipidemics | 2453 (13.7) | 119 (15.0) | 0.292 | 1908 (11.8) | 69 (12.3) | 0.780 |
Anti-hypertensives | 4478 (25.0) | 224 (28.3) | 0.035 | 3471 (21.5) | 137 (24.3) | 0.110 |
Beta blockers | 2474 (13.8) | 122 (15.4) | 0.208 | 1873 (11.6) | 76 (13.6) | 0.179 |
Other medications | 5152 (28.7) | 257 (32.5) | 0.023 | 4025 (24.9) | 156 (27.9) | 0.135 |
Antibiotics | 3355 (18.7) | 209 (26.5) | <0.001 | 2704 (16.7) | 120 (21.3) | 0.005 |
Antihistamines | 4437 (24.7) | 295 (37.3) | <0.001 | 4117 (25.5) | 224 (40.0%) | <0.001 |
Nasal corticosteroids | 3744 (20.9) | 244 (30.9) | <0.001 | 3458 (21.4) | 191 (34.1) | <0.001 |
Antidepressant | 3039 (16.9) | 155 (19.6) | 0.056 | 2565 (15.9) | 103 (18.4) | 0.131 |
Hypnotics | 1989 (11.1) | 116 (14.7) | 0.002 | 1592 (9.9) | 75 (13.4) | 0.008 |
Antianxiety | 2778 (15.5) | 134 (16.9) | 0.286 | 2196 (13.6) | 78 (13.8) | 0.888 |
Bisphosphonates | 343 (1.9) | 34 (4.3) | <0.001 | 231 (1.4) | 14 (2.4) | 0.060 |
Calcium D vitamine | 63 (0.3) | 9 (1.2) | 0.001 | 57 (0.4) | 4 (0.8) | 0.302 |