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Fig. 8 | Respiratory Research

Fig. 8

From: Role and regulation of Abelson tyrosine kinase in Crk-associated substrate/profilin-1 interaction and airway smooth muscle contraction

Fig. 8

Novel mechanisms for regulation of actin dynamics. Upon agonist activation, c-Abl mediates CAS phosphorylation, which promotes the association of CAS with Pfn-1 to activate Pfn-1. In addition, c-Abl also catalyzes cortactin phosphorylation and increases the coupling of cortactin with Pfn-1. Activated Pfn-1 facilitates actin polymerization. Src mediates c-Abl activation in response to contractile stimulation. Furthermore, actin polymerization provides a positive feedback for c-Abl activation

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