Fig. 2

Effects of supra-physiologic levels of GM-CSF on lung mechanical properties during IAV infection. Pressure-volume (PV) curves showing the mean±SEM of lung volume (mL) of each group, LM (black) and DTGM (red) at each indicated preprogramed pressure (cmH₂O) at 7 dpi (a) and at 10 dpi (b)(n = 5-9 mice per group per time point). The PV curves of uninfected mice (gray) are shown on each graph for comparison. Shown are the lung mechanical parameters of static compliance (Cst, mL*cmH₂O⁻¹)(c), total respiratory system resistance (Rrs, cmH₂O*s⁻¹*mL⁻¹)(d), tissue damping or peripheral airway resistance (G, cmH₂O*s⁻¹*mL⁻¹)(e),Newtonian or central airway resistance (Rn, cmH₂O*s⁻¹*mL⁻¹)(f), and the curvature of the deflation limb of the PV curve (K, cmH₂O⁻¹)(g). Results shown represent three independent experiments, n = 4-10 mice per group per time point (*p < 0.05)