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Fig. 6 | Respiratory Research

Fig. 6

From: Mesenchymal stromal cell-derived extracellular vesicles attenuate lung ischemia-reperfusion injury and enhance reconditioning of donor lungs after circulatory death

Fig. 6

MSCs and EVs attenuate neutrophil transendothelial migration in lung microvascular endothelial cells (LMECs). a Schematic showing the transwell cell culture model used to assess neutrophil transendothelial migration. Primary murine neutrophils were added to LMEC monolayer co-cultured with or without MSCs or EVs. b Exposure of LMECs to HR and cytomix (cyto; HMGB1 and TNF-α; 50 ng/ml each) for 4 h showed a significant increase in neutrophil transmigration, which was significantly attenuated by co-cultures with MSCs or EVs. n = 8/group; *, p < 0.05 vs. all

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Respiratory Research

ISSN: 1465-993X

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