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Fig. 4 | Respiratory Research

Fig. 4

From: Mesenchymal stromal cell-derived extracellular vesicles attenuate lung ischemia-reperfusion injury and enhance reconditioning of donor lungs after circulatory death

Fig. 4

MSCs and EVs inhibit macrophage and iNKT cell activation after HR. a-b MH-S (alveolar macrophages) cells were exposed to hypoxia/reoxygenation (HR) and demonstrated a significant increase in HMGB1 and TNF-α production compared to normoxia (Norm) which was significantly attenuated by treatment with MSCs or EVs. c Similarly, HR-exposed iNKT cells produced increased levels of IL-17 compared to normoxia which was significantly attenuated by treatment with MSCs or EVs. n = 5/group; *, p < 0.05 vs. all

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Respiratory Research

ISSN: 1465-993X

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