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Fig. 3 | Respiratory Research

Fig. 3

From: Mesenchymal stromal cell-derived extracellular vesicles attenuate lung ischemia-reperfusion injury and enhance reconditioning of donor lungs after circulatory death

Fig. 3

Lung inflammation after IR is attenuated by MSCs or EVs. Proinflammatory cytokine levels (IL-17, TNF-α, HMGB1, CXCL1, MCP-1, IL-6, MIP-1α and RANTES) were significantly attenuated in BAL fluid after IR in mice treated with MSCs or EVs versus IR alone. Anti-inflammatory cytokine (IL-10) expression as well as keratinocyte growth factor (KGF) and prostaglandin E2 (PGE2) levels were significantly increased in BAL fluid after treatment with MSCs or EVs after IR compared to IR alone. n = 5/group; *p < 0.05 vs. all; #p < 0.05 vs. IR

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Respiratory Research

ISSN: 1465-993X

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