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Fig. 2 | Respiratory Research

Fig. 2

From: Mesenchymal stromal cell-derived extracellular vesicles attenuate lung ischemia-reperfusion injury and enhance reconditioning of donor lungs after circulatory death

Fig. 2

MSCs or EVs decrease neutrophil infiltration and activation as well as lung edema after IR. a Representative images showing neutrophil immunostaining in lung sections. Neutrophils are stained red and sections are counterstained with hematoxylin. Scale bars indicate 50 μm. b The number of neutrophils per high power field (HPF) was quantified from immunostained sections. Neutrophil infiltration was significantly attenuated after IR in mice treated with MSCs or EVs compared to untreated mice. c Myeloperoxidase (MPO) levels in bronchoalveolar lavage fluid was significantly decreased after IR in mice treated with MSCs or EVs. d Pulmonary edema (lung wet/dry weight) was significantly decreased after IR in wild-type mice treated with MSCs or EVs compared to untreated mice. n = 5/group; *p < 0.05 vs. all

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