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Fig. 1 | Respiratory Research

Fig. 1

From: A role for B cells in organic dust induced lung inflammation

Fig. 1

Airway inflammatory cell influx and mediator response following repetitive ODE exposure in B-cell receptor (BCR) knockout mice (KO) mice. Mice were intranasally treated with saline or organic dust extract (ODE) daily for 3 weeks and bronchoalveolar lavage fluid (BALF) was collected 5 h following final exposure. Bar graphs of means with standard error bars of a total cells and cell differentials and b cytokine/chemokine levels quantitated in BALF are shown. c Mean levels with standard error bars of B-cell chemotactic mediators IL-17A and hyaluronan quantitated in lung tissue homogenates are shown. There is no difference in ODE-induced cellular influx, IL-17A, or hyaluronan between WT and KO mice. ODE-induced TNF-α, IL-6, murine neutrophil chemoattractants (CXCL1 and CXCL2) response were reduced in BCR KO animals. N = 6 mice/treatment group from 2 independent experiments. Statistical significance (*p < 0.05, **p < 0.01, ***p < 0.001) vs. matched saline. Significant differences between WT and BCR KO denoted by line (#p < 0.05, ##p < 0.01)

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